A histopathological study on spontaneous gastrointestinal epithelial tumors          in dogs

Saito, Tsubasa; Nibe, Kazumi; Chambers, James K.; Uneyama, Mizuho; Nakashima, Ko; Ohno, Koichi; Tsujimoto, Hajime; Uchida, Kazuyuki; Nakayama, Hiroyuki

doi:10.1293/tox.2019-0076

Cited by 17 publications

(32 citation statements)

References 33 publications

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“…These specimens were subjected to IHC for beta-catenin, E-cadherin and p53. The details of the histopathological features, age, sex, and breed predisposition were described in the previous paper [ 48 ].…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we described the histopathological features, age, sex, and breed predisposition of canine gastrointestinal epithelial tumors [48]. This paper focuses on immunohistochemical features of these tumors.…”

Section: E-cadherin Is a Calcium-dependent Cell-cell Adhesion Moleculmentioning

confidence: 99%

“…Russell Terriers and Miniature Dachshunds were the breeds with the highest predisposition for gastrointestinal tumors, and Jack Russel terrier was frequently involved in polypoid formed tumors [48]. Recently, a somatic mutation and loss of the wild-type APC allele have been reported in the canine breed with gastrointestinal tumors [62].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a somatic mutation and loss of the wild-type APC allele have been reported in the canine breed with gastrointestinal tumors [62]. By contrast, adenocarcinoma shows not only polypoid formation but also occasionally lacked polypoid characteristics and the lesions are flat or depressed in humans and dogs [48,52]. These carcinomas are considered to be de novo because the lesions were small and develop without any intervening precursor lesion [7,30].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the tumors in the FAP patients or APC min mice are generally formed by polypoid growth and the tumorigenesis is considered to be through the adenoma-carcinoma sequence [ 41 ]. We previously showed that Jack Russell Terriers and Miniature Dachshunds were the breeds with the highest predisposition for gastrointestinal tumors, and Jack Russel Terrier was frequently involved in polypoid formed tumors [ 48 ]. Recently, a somatic mutation and loss of the wild-type APC allele have been reported in the canine breed with gastrointestinal tumors [ 62 ].…”

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confidence: 99%

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Immunohistochemical analysis of beta-catenin, E-cadherin and p53 in canine gastrointestinal epithelial tumors

et al. 2020

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Wnt/beta-catenin signaling, E-cadherin and p53 reportedly play important roles in the development and/or progression of human gastrointestinal cancer. The present study evaluated the roles of beta-catenin, E-cadherin and p53 in canine gastrointestinal tumors. Endoscopic biopsy or surgically resected samples, a total of 131, including 38 gastric, 13 small intestinal and 80 large intestinal tumors, were obtained from 95 dogs. Those specimens were examined pathologically. Immunohistochemically, nuclear beta-catenin expression was found in 88% (42/48) of polypoid type adenocarcinomas. Most cases of non-polypoid type adenocarcinomas lacked nuclear expression of beta-catenin with the exception of one case (6%, 1/17). Nuclear beta-catenin expression was not observed in signet ring cell carcinomas (0/15), mucinous adenocarcinomas (0/7) and undifferentiated carcinomas (0/4). The findings indicate that nuclear translocation of beta-catenin is closely related to the development of polypoid type adenocarcinomas but not that of non-polypoid type malignant tumors. The immunoreactivity of E-cadherin for tumor cells tended to decline overall in most of cases including benign tumors. Significant immunoreactivity for p53 was not found in 61% of tumors examined (80/131), including malignant tumors (63%, 57/91), while intense p53-immunoreactivity was rarely found in a few cases of malignant tumors (8%, 7/91). We could not conclude clearly significant correlations between histopathological tumor types and immunohistochemical results of E-cadherin or p53. This paper indicates the importance of the nuclear translocation of beta-catenin for the tumorigenesis of canine intestinal polypoid type adenocarcinomas, especially in the colorectum.

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Section: Methodsmentioning

confidence: 99%

Section: E-cadherin Is a Calcium-dependent Cell-cell Adhesion Moleculmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Immunohistochemical analysis of beta-catenin, E-cadherin and p53 in canine gastrointestinal epithelial tumors

et al. 2020

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Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases

Méric,

Issard,

Maufras

et al. 2023

Veterinary Internal Medicne

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BackgroundCompared to humans, colorectal polyps are relatively rare in dogs. Epidemiological and prognostic data remain accordingly sparse, although they could help veterinary clinicians in the management of these cases.ObjectivesTo report the epidemiological data of dogs with colorectal polyps and identify factors associated with recurrence and survival.AnimalsFifty‐eight client‐owned dogs with colorectal polyps admitted to 7 veterinary hospitals (53 dogs from France, 5 dogs from Spain, and 4 dogs from Portugal) were included.MethodsRetrospective multicentric cohort study. Medical records and long‐term outcome of the dogs were reviewed. When available, histological samples were reassessed by 2 board‐certified pathologists according to the revised Vienna classification (RVC).ResultsThe West Highland White Terrier (WHWT) breed was significantly associated with the presence of colorectal polyps (OR: 20; 95% CI: 7.5‐52; P < .001). The overall median time to recurrence was not reached after 2000 days. The overall estimated median survival time was 1640 days. WHWT breed and larger polyps were significantly associated with a shorter time of polyp recurrence after surgical removal (respectively, P = .05 and P = .01).Conclusions and Clinical ImportanceThe probability of recurrence of colorectal polyps in dogs is low, but increased in WHWTs and larger polyps, which might benefit from routine screening after removal. No effective predictors of polyp recurrence and survival were identified using the RVC.

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Vimentin and Ki-67 immunolabeling in canine gastric carcinomas and their prognostic value

et al. 2022

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This study evaluated the expression of vimentin and Ki-67 proliferative index (PI) by immunohistochemistry in 30 canine gastric carcinomas (GCs) and a possible association with clinical and pathological features and patient’s survival time. Vimentin immunoreactivity was assessed in neoplastic cells (in primary lesions, emboli, and metastases) and tumor-associated stroma (TAS) of canine GCs. Ki-67 PI was quantified in the neoplastic epithelial component. Vimentin immunolabeling in neoplastic cells was found in 30% of the primary lesions, in 82% of the neoplastic emboli, and in 50% of the metastases; in TAS, it was observed in all cases. A mean of 16% of the TAS was immunolabeled for vimentin. High vimentin immunolabeling in the TAS (>16%) was detected in 40% of cases. The average value of Ki-67 PI was 50%, and 80% of the lesions had Ki-67 PI above 20%. Vimentin immunolabeling in neoplastic cells was more frequent in less-differentiated carcinomas (diffuse [29%] and indeterminate types [75%]) than well-differentiated carcinomas (intestinal type [0%], P = .049). No significant differences were observed in vimentin immunolabeling in the TAS or Ki-67 PI according to histological diagnosis, depth of invasion, presence of neoplastic emboli or metastases. However, vimentin immunolabeling in the TAS was positively correlated with Ki-67 PI ( r = .394, P = .031). Furthermore, a moderate negative correlation was observed between Ki-67 PI and survival time ( r = −0.540). Our results suggest that vimentin and Ki-67 PI have potential for providing prognostic information in cases of canine GCs.

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A histopathological study on spontaneous gastrointestinal epithelial tumors in dogs

Cited by 17 publications

References 33 publications

Immunohistochemical analysis of beta-catenin, E-cadherin and p53 in canine gastrointestinal epithelial tumors

Immunohistochemical analysis of beta-catenin, E-cadherin and p53 in canine gastrointestinal epithelial tumors

Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases

Vimentin and Ki-67 immunolabeling in canine gastric carcinomas and their prognostic value

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