A Historical Review of Early Descriptions of Adamantiades-Behçet's Disease

Zouboulis, Christos C.; Keitel, W

doi:10.1046/j.1523-1747.2002.01798.x

Cited by 52 publications

(23 citation statements)

References 26 publications

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“…Hulûsi Behçet , türkischer Dermatologe, publizierte seit 1937 Krankheitsbeschreibungen von Patienten mit rezidivierenden Läsionen am Mund, an den Genitalien und den Augen und fügte dem Symptomenkatalog Periodontitis, Kieferzysten, akneiforme Hautveränderungen und Erythema nodosum sowie Arthralgien hinzu. Behçets intensive Beschäfti-gung mit der Erkrankung und seine Über-zeugung von ihrem eigenständigen Charakter lenkten endgültig die Aufmerksamkeit der wissenschaftlichen Öffentlich-keit auf diese Krankheit, [26]. Aufgrund der historischen Würdigung beider Autoren wurden das Krankheitsbild, das heute als chronisch rezidivierende Systemvaskulitis angesehen wird, sowie unser epidemiologisches Register mit dem Namen beider bezeichnet.…”

Section: Epidemiologie Und Klinik Des Morbus Adamantiades-behçet In Dunclassified

Epidemiologie und Klinik des Morbus Adamantiades-Behçet in Deutschland

et al. 2012

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Of the 721 documented patients in the German Registry for Adamantiades-Behçet disease (registered charity), 258 were of German and 308 of Turkish descent, along with 30 other countries of origin. The prevalence in Germany is 0.9:100,000. Manifestation of the disease was predominantly in the third decade of life (median age: 26.5 years) and in 10.7% the disease onset was under 16 years of age. The full clinical picture developed on average in 2.9 years (median 3 months). Patients of Turkish descent showed androtopism in contrast to those of German descent (female:male 1.9:1), which was also detected in the whole collective in a ratio of 1.4:1. In 12.4% there was a family history with differences between German and Turkish patients (3.8% versus 14.6%) as well as in patients with disease onset in young and adult age (25.0% versus 7.3%). Most frequent features included oral aphthae (98.5%), cutaneous lesions (81%), genital ulcers (64.7%), ocular manifestations (51.6%), arthritis (52.4%) and positive pathergy test (30.8%). Turkish patients suffered significantly more often from eye manifestations compared with Germans, while in German patients prostatitis/epididymitis and gastrointestinal involvement were more frequently documented. As serious complications arose blindness 6.8%, meningoencephalitis 4.0%, severe arthritis 2.6%, fatal outcome 1.2%, hemoptysis 1.1% and gastrointestinal perforation 0.5%. The HLA-B5 antigen was positive in 58.1% and showed an association with eye manifestations. The relative risk of HLA-B5 positive individuals is high in both Germans (6.57) and Turks (5.81).

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Section: Epidemiologie Und Klinik Des Morbus Adamantiades-behçet In Dunclassified

Epidemiologie und Klinik des Morbus Adamantiades-Behçet in Deutschland

et al. 2012

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“…Elle peut concerner quasiment tous les organes et est actuellement classées au sein des vascularites primitives non nécrosantes [2, 3]. Sa prévalence étant maximale dans les pays du bassin méditerranéen et l'Asie et, surtout, en turquie, ou la prévalence est estimée entre 1/10 000 et 1/1 000 habitants [4, 5].…”

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Behçet oculaire

Alami¹,

Kriet²,

Karim³

et al. 2017

Pan Afr Med J

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L'objectif était de déterminer les caractéristiques cliniques, thérapeutiques et pronostiques de l'atteinte oculaire chez les patients atteints de la maladie de Behçet, pris en charge dans notre service d'ophtalmologie. Nous présentons une étude rétrospective d'une série de 20 patients colligés à l'hôpital militaire de Laâyoune. Les patients ont bénéficié d'un examen ophtalmologique complet, d'une angiographie à la fluorescéine si nécessaire. Un examen OCT est réalisé chez deux patients. Dix cas d'uvéite antérieure dont un cas s'est compliqué d'hypertonie oculaire; Deux cas d'uvéite intermédiaire; huit cas d'atteinte du segment postérieur dont un cas s'est compliqué d'hémorragie intravitrienne. La maladie de Behçet (MB) est une affection inflammatoire systémique idiopathique actuellement classées au sein des vascularites primitives non nécrosantes. L'atteinte oculaire de la maladie de Behçet est fréquente et grave, mettant en jeu le pronostic visuel des patients. La maladie de Behçet est fréquente au Maroc, engageant le pronostic visuel, rendant la collaboration entre ophtalmologistes et internistes particulièrement importante.

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“…Behçet's disease [1] (Adamantiades-Behçet's disease [2–4]) (ABD) is a chronic and multisystematic inflammatory disorder characterized by starting with oral ulceration and develops the recurrent involvement of mucocutaneous (oral and genital ulceration, acne-like eruption, erythema nodosum- (EN-) like eruption, etc. ), ocular, vascular, digestive, and/or nervous system organs.…”

Section: Introductionmentioning

confidence: 99%

Behçet's Disease (Adamantiades-Behçet's Disease)

Kaneko

Togashi

Saito

et al. 2011

Clinical and Developmental Immunology

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Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues. Bes-1 gene encoded partial S. sanguinis genome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.

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A Historical Review of Early Descriptions of Adamantiades-Behçet's Disease

Abstract: Adamantiades±Behc Ëet's disease is a chronic, multisystemic in¯ammatory disorder, which is clinically characterized by relapsing oral aphthous and genital ulcers, and ocular vascular lesions (Kaklamani

Cited by 52 publications

References 26 publications

Epidemiologie und Klinik des Morbus Adamantiades-Behçet in Deutschland

Epidemiologie und Klinik des Morbus Adamantiades-Behçet in Deutschland

Behçet oculaire

Behçet's Disease (Adamantiades-Behçet's Disease)

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