This paper shows that the relationship between solar EUV flux and the F10.7 index during the extended solar minimum (Smin) of 2007–2009 is different from that in the previous Smin. This difference is also seen in the relationship between foF2 and F10.7. We collected SOHO/SEM EUV observations and the F10.7 index, through June 2010, to investigate solar irradiance in the recent Smin. We find that, owing to F10.7 and solar EUV flux decreased from the last Smin to the recent one with different amplitudes (larger in EUV flux), EUV flux is significantly lower in the recent Smin than in the last one for the same F10.7. Namely, F10.7 does not describe solar EUV irradiance in the recent Smin as it did in the last Smin. That caused remarkable responses in ionospheric foF2. For the same F10.7, foF2 in the recent Smin is lower than that in the last one; further, it is also lower than that in other previous Smins. Therefore, F10.7 is not an ideal indicator of foF2 during the recent Smin, which implies that F10.7 is not an ideal proxy for solar EUV irradiance during this period, although it has been adequate during previous Smins. Solar irradiance models and ionospheric models will need to take this into account for solar cycle investigations.