A Hollow-Fiber Membrane Extraction Process for Recovery and Separation of Lactic Acid from Aqueous Solution

Huang, Hongwei; Yang, Shang‐Tian; Ramey, David E.

doi:10.1007/978-1-59259-837-3_54

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…Continuous lactic acid removal by membrane based processes has been shown to effectively increase lactic acid productivity [10]. Although several organic solvents containing the tertiary amine Alamine 336 [11], the secondary amine Amberlite LA-2 [12], tri-n-octylamine or tributylphosphate [13,14] have been studied for efficient lactic acid reactive extraction, an economical method for lactic acid recovery from the fermentation broth is still needed. Micellar-enhanced ultrafiltration (MEUF) is an alternative process that can be used for organic acids recovery.…”

Section: Introductionmentioning

confidence: 99%

Lactic acid recovery by microfiltration using niosomes as extraction agents

Roque

Escudero

Benito

2015

Separation and Purification Technology

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Section: Introductionmentioning

confidence: 99%

Lactic acid recovery by microfiltration using niosomes as extraction agents

Roque

Escudero

Benito

2015

Separation and Purification Technology

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“…To overcome the aforementioned issues, efforts have been made to assimilate different techniques with lactic acid production and recovery, such as membrane processes,2–8 solvent extraction,9–14 electrodialysis,15–17 ion exchange, and adsorption 18–21. However, membrane fouling, low selectivity of polymeric solvents in solvent extraction, fouling of electrodialysis membranes, and energy consumption costs are unresolved issues associated with these technologies.…”

Section: Introductionmentioning

confidence: 99%

Investigation of a dual‐particle liquid–solid circulating fluidized bed bioreactor for extractive fermentation of lactic acid

Patel¹,

Bassi²,

Zhu³

et al. 2008

Biotechnology Progress

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A dual-particle liquid-solid circulating fluidized bed (DP-LSCFB) bioreactor has been constructed and investigated for the simultaneous production and extraction of lactic acid using immobilized Lactobacillus bulgaricus and ion-exchange resins. The apparatus consisted of a downer fluidized bed, 13 cm I.D. and 4.75 m tall, and a riser fluidized bed, 3.8 cm I.D. and 5.15 m in height. The lactic acid production and removal was carried out in the downer, while the riser was used for the recovery of lactic acid. A continuously recirculating bed of ion-exchange resin was used for adsorption of the produced acid as well as for maintaining optimum pH for bioconversion, thus eliminating the need for costly and complex chemical control approach used in conventional techniques. Studies using lactic acid aqueous solution as feed and sodium hydroxide solution as regeneration stream showed 93% lactic acid removal from the downer and 46% recovery in the riser under the conditions investigated. Such results prove the functionality of using the newly developed bioreactor design for the continuous production and recovery of products of biotechnological significance.

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“…A simplified approach derived from the model of Huang et al 34 was adopted for extraction through the membranes, assuming that re-extraction was a nonlimiting process for C6 accumulation in the alkaline solution, which was regularly replaced to avoid excessively high C6 concentrations. Moreover, a single extraction coefficient was assumed (k ext ) for the reactive extraction (dependent on the TOPO concentration) and physical extraction due to the invariable TOPO concentrations.…”

Section: Methodsmentioning

confidence: 99%

Optimal pH set point for simultaneous production and pertraction of n‐caproic acid: an experimental and simulation study

Gehring

Cavalcante

Colares

et al. 2020

J of Chemical Tech & Biotech

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BACKGROUND: The high rate production of n-caproic acid (C6) through chain elongation can be achieved with the use of pertraction systems for the continuous and selective extraction of C6. However, although the biological conversion processes are enhanced at a neutral pH, high extraction efficiency depends on acidic conditions. Understanding of these divergent pH effects is fundamental for a reliable operation and scale-up of these C6-producing systems. RESULTS: A bench-scale anaerobic filter (12.8 L) fed with fermented sugarcane at organic loading rates of ≈7.2 g of chemical oxygen demand (COD) L −1 day −1 achieved C6 production rates of 2.1 and 3.8 g COD L −1 day −1 , without and with in-line extraction, respectively. Compared to previous studies, a high average extraction rate of 24.7 g COD m −2 day −1 was observed due to a high reactor volume-to-membrane-area ratio. The novel model described here with biological and pertraction processes for continuously operated systems indicates that an optimal operative pH can simultaneously maximize C6 production and extraction. The hydraulic retention time was another key parameter for balancing inhibition by undissociated C6 and losses due to nonextracted C6. CONCLUSIONS: Sugarcane biorefineries can produce C6, which has a market value that is >10-fold higher than ethanol. Simulations of chain elongation processes require the implementation of hydrogenotrophic methanogens to allow for a comprehensive description of ethanol consumption together with the C6 formation, in-line C6 extraction processes, and formation of gaseous by-products. Although these simulations were possible using parameter sets from the literature, further studies are needed for parameter identification, especially under inhibition at low pH.

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A Hollow-Fiber Membrane Extraction Process for Recovery and Separation of Lactic Acid from Aqueous Solution

Cited by 8 publications

References 25 publications

Lactic acid recovery by microfiltration using niosomes as extraction agents

Lactic acid recovery by microfiltration using niosomes as extraction agents

Investigation of a dual‐particle liquid–solid circulating fluidized bed bioreactor for extractive fermentation of lactic acid

Optimal pH set point for simultaneous production and pertraction of n‐caproic acid: an experimental and simulation study

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