A homochiral polar molecular piezoelectric material with phase transition and high piezoelectricity precisely designed by cyanomethyl group substitution

Yang, Shu-Jing; Bai, Yong-Ju; Qi, Jun-Chao; Huang, Xiao-Yun; Shen, Xin; Lu, Yan-Zi; Xia, Zhang-Tian; Lv, Hui-Peng; Liao, Wei-Qiang

doi:10.1039/d4ce00023d

CrystEngComm

2024

DOI: 10.1039/d4ce00023d

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A homochiral polar molecular piezoelectric material with phase transition and high piezoelectricity precisely designed by cyanomethyl group substitution

Shu-Jing Yang,

Yong-Ju Bai,

Jun-Chao Qi

et al.

Abstract: A chiral non-polar SHG inactive compound without phase transition is transformed into a chiral polar SHG active compound with phase transition by the introduction of cyanomethyl group, and the d22 value is raised significantly from 0 to 18 pC/N.

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Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review

Hulimane Shivaswamy,

Binulal,

Benoy

et al. 2024

ACS Mater. Au

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The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged as a prominent area of focus in biomedical research because of its ability to deliver a wide range of biomolecules, vaccines, medicines, and other substances through the skin. Microneedles (MNs) form microchannels by disrupting the skin's structure, which compromises its barrier function, and facilitating the easy penetration of drugs into the skin. These devices enhance the administration of many therapeutic substances to the skin, enhancing their stability. Transcutaneous delivery of medications using a microneedle patch offers advantages over conventional drug administration methods. Microneedles containing active substances can be stimulated by different internal and external factors to result in the regulated release of the substances. To achieve efficient drug administration to the desired location, it is necessary to consider the design of needles with appropriate optimized characteristics. The choice of materials for developing and manufacturing these devices is vital in determining the pharmacodynamics and pharmacokinetics of drug delivery. This article provides the most recent update and overview of the numerous microneedle systems that utilize different activators to stimulate the release of active components from the microneedles. Further, it discusses the materials utilized for producing microneedles and the design strategies important in managing the release of drugs. An explanation of the commonly employed fabrication techniques in biomedical applications and electronics, particularly for integrated microneedle drug delivery systems, is discussed. To successfully implement microneedle technology in clinical settings, it is essential to comprehensively assess several factors, such as biocompatibility, drug stability, safety, and production cost. Finally, an in-depth review of these criteria and the difficulties and potential future direction of microneedles in delivering drugs and monitoring diseases is explored.

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Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review

Hulimane Shivaswamy,

Binulal,

Benoy

et al. 2024

ACS Mater. Au

View full text Add to dashboard Cite

show abstract

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A homochiral polar molecular piezoelectric material with phase transition and high piezoelectricity precisely designed by cyanomethyl group substitution

Abstract: A chiral non-polar SHG inactive compound without phase transition is transformed into a chiral polar SHG active compound with phase transition by the introduction of cyanomethyl group, and the d22 value is raised significantly from 0 to 18 pC/N.

Cited by 1 publication

References 53 publications

Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review

Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review

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