“…Variants in the CYBA , CYBB , NCF1 , NCF2 (OMIM *608,515), NCF4, and CYBC1 genes, which code for the six components of this enzyme complex, lead to CGD (Roos et al, 2010). Hemizygous variants in the CYBB gene, which encodes the gp91 phox subunit of the NADPH oxidase complex, lead to X‐linked recessive (XL) CGD, while bi‐allelic variants in the CYBA , NCF1 , NCF2 , NCF4, and CYBC1 genes, which encode the p22 phox , p47 phox , p67 phox , p40 phox , and EROS subunits, respectively, lead to different forms of autosomal recessive (AR) disease (Arnadottir et al, 2018; Chiriaco, Salfa, Di Matteo, Rossi, & Finocchi, 2016; Roos et al, 2010; Thomas et al, 2017). CGD is characterized by recurrent bacterial, including mycobacterial, and fungal infections, resulting in granulomas, episodes of fever, rash, and other symptoms, such as colitis (Roos et al, 2010).…”