“…Although cluster headaches have been reported to respond to indomethacin, 8 this feature usually suggests paroxysmal hemicrania 2 and raises the possibility that this phenomenon may be relevant to the trigeminal autonomic cephalgias (TAC) as a group, all of which are associated with the posterior hypothalamus. 9 The sympathetic nervous system is believed to be associated with TAC in a passive manner 1 ; however, in some cases, there is evidence of sympathetic dysfunction before the onset of TAC, 10 suggesting that sympathetic underactivity may underlie TAC pathogenesis. If TAC pain is dependent on low sympathetic tone, theoretically the episode could be reversed by the increase in sympathetic activity accompanying sexual activity and, specifically, orgasm.…”