A hospital-based study of clinical and genetic features of Crohn’s disease

Abstract

Recently, the incidence of CD diagnosis in Taiwan has markedly increased. ATG16L1 and TNFSF15 are associated with CD in Taiwan.

Long-term follow-up of ulcerative colitis in Taiwan

“…In addition to our previous reports on CD patients, 10,11 our results show that the incidence of IBD in general in Taiwan has also increased. According to the registration record in the Bureau of National Health Insurance of Taiwan, 1560 UC patients had been registered before 2008.…”

An Envirogenomic Signature Is Associated with Risk of IBD-Related Surgery in a Population-Based Crohn’s Disease Cohort

“…However studies where clinical, genetic and environmental data have been combined and analysed in a systematic way to yield an envirogenomic profile for estimating the risk of complicated disease and surgical intervention have not been performed previously. Previous studies have also shown independent predictor models for various individual risk factors 14 as well as formulated tools to predict the development of complicated CD using independent risk factors 17 ; however, the multifactor model developed in this study produces a much higher predictive probability for the risk of surgery then when any of the risk factors are considered independently, indicating the usefulness of the method of research utilised in this study. Consequently, our multi-factor envirogenomic risk model has taken a step closer to identifying patients at risk for the need of surgery potentially allowing early and personalised therapeutic decisions to be made that can prevent the development of complicated disease.…”

“…[4][5][6][7][8]18 Smoking has also been associated with the development and progression of CD, 6,8,[12][13][14]18 increasing the risk for IBD-related surgery. Similarly, perianal disease is associated with an increased risk of progressive complicated CD [8][9][10][11] and resectional surgery.…”

“…2,3 A range of factors have been associated with an increased risk of complicated (stricturing and penetrating) CD behaviour including the specific NOD2 genotypes [4][5][6] having had perianal disease [8][9][10][11] and cigarette smoking. 1,6,8,[12][13][14] Complicated disease is strongly associated with a requirement for surgery 15 ; therefore, knowledge of such genetic, environmental and clinical predictors may guide clinicians in developing a personalised approach for individual patients. 2,3,16 The ability to predict those who will have a more indolent disease course is also important given the range of adverse drug reactions and the cost of anti-TNF drugs.…”

A rare complication of Crohn disease: Duodenocolic fistula

“…Fistulas are frequently seen in the CD, whereas duodenocolic fistulas are rare. In the study conducted by Wei et al (2), the rate of fistula has been observed as 24.6%. Feculent vomiting and foulsmelling eructation are characteristic, whereas weight loss, abdominal pain, and diarrhea are uncharacteristic symptoms of the disease (3).…”