A Hospital Based Study Regarding Awareness of Association Between Glycosylated Haemoglobin and Severity of Diabetic Retinopathy in Type 2 Diabetic Individuals

Prabhu, Mukhyaprana; Kakhandaki, Anupama; Kr, Chandra; Mb, Dinesh

doi:10.7860/jcdr/2016/15834.7014

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…The findings of this study regarding HbA1c levels were consistent with those of other studies despite the fact that the current study enrolled patients with HbA1c levels as low as 7.0% (53 mmol/mol) [14]. Prabhu M et al [15] showed that only 23 (11.5%) patients enrolled in their study were aware of the importance of HbA1c levels. Moreover, the authors of that study noted that the proportion of patients who achieved the target HbA1c level of <7% (53 mmol/mol) was low in patients with DR.…”

Section: Discussionsupporting

confidence: 89%

Early changes in pulmonary function and intrarenal haemodynamics and the correlation between these sets of parameters in patients with T2DM

et al. 2019

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PurposeThe main objectives of this study were to assess the early changes in pulmonary function and intrarenal haemodynamics and to determine the correlation between pulmonary function and intrarenal haemodynamics in patients with type 2 diabetes mellitus (T2DM).Methods96 patients with T2DM (diabetes group) without diabetes kidney disease (DKD) and 33 healthy subjects (control group) were enrolled in studies intended to assess the early changes in pulmonary function and intrarenal haemodynamics associated with diabetes, as well as to determine the correlation between pulmonary function and intrarenal haemodynamics.ResultsPulmonary functional parameters were negatively correlated with HbA1c levels and diabetes duration (P< 0.05). Moreover, renal functional parameters were positively correlated with HbA1c levels and diabetes duration (P<0.05). Additionally, pulmonary functional parameters were negatively correlated with renal functional parameters (P<0.05). Multiple linear regression analysis of the relationship between pulmonary functional parameters and the bilateral kidney arterial resistivity index (RI) showed that all the pulmonary functional parameters were significantly correlated with the arterial RI (P< 0.05).ConclusionsPatients displayed changes in pulmonary function and intrarenal haemodynamics during the preclinical stages of DKD. Regulating glycaemia may improve intrarenal haemodynamics in the bilateral interlobular renal arteries. Moreover, during the preclinical stages of DKD, the right kidney RI is a effective predictor of early changes in pulmonary function in adult T2DM patients.Trial registrationClinicalTrials.gov (NCT02798198); registered 8 June 2016.

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Section: Discussionsupporting

confidence: 89%

Early changes in pulmonary function and intrarenal haemodynamics and the correlation between these sets of parameters in patients with T2DM

et al. 2019

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“…In this case, most of our participants were Caucasian. One should be cautious in extrapolating this information to other races, but similar data were observed in Australia (12), Europe (16), Asia (14) and the United States (12,14,15). Although our sample size was small, our findings coincide with those showing diabetes knowledge amongst patients is low and they lack awareness of ocular complications, including blindness (12,14).…”

Section: Discussionsupporting

confidence: 79%

Baseline Diabetes Knowledge Assessment Amongst Adults With Type 1 and Type 2 Diabetes Receiving Eye Care at a Tertiary Ophthalmic Centre in Canada

Sivachandran

Ahmad

Qian

et al. 2021

Canadian Journal of Diabetes

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Patients with poor knowledge about their disease status are more likely to have poor clinical outcomes and worse prognosis. Patients receiving care for diabetic retinopathy have low baseline diabetes knowledge in a tertiary setting in Canada. Collaborative effort amongst primary care physicians and specialists can improve baseline knowledge of diabetes and its complications. Patients can be empowered to take ownership of their health and improve outcomes, including blindness related to diabetic retinopathy.

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“…The role of poor glycemic control in development and progression of diabetic retinopathy and DME cannot be overlooked [28]. Therefore, we included patients with glycosylated hemoglobin less than 8% in a trial to eliminate that possible confounding factor.…”

Section: Discussionmentioning

confidence: 99%

Switching to Aflibercept in Diabetic Macular Edema after Unsatisfactory Response to Other Anti-vascular Endothelial Growth Factor Drugs

Ibrahim

Eldaly

Saleh

et al. 2019

Korean J Ophthalmol

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Purpose To evaluate the efficacy of switching to aflibercept in diabetic macular edema (DME) with suboptimal response to previous anti-vascular endothelial growth factor (anti-VEGF) injections. Methods A prospective interventional case series study recruited patients from a single center diagnosed with DME with suboptimal response to anti-VEGF injections. Three consecutive monthly injections of aflibercept were performed. The primary outcome measure was mean change in visual acuity after switching to aflibercept. Results Forty-two patients (42 eyes) were included. Baseline logarithm of the minimum angle of resolution (logMAR) visual acuity was 0.87 ± 0.23 and improved significantly to 0.62 ± 0.29, 0.56 ± 0.34, and 0.46 ± 0.35 at 1, 2, and 3 months, respectively, after the first injection. Mean baseline retinal thickness was 451.57 ± 107.09 µm and decreased significantly at 1, 2, and 3 months after switching to aflibercept (346.52 ± 79.03, 328.24 ± 81.98, and 313.71 ± 85.79 µm, respectively). Both visual improvement and mean change in retinal thickness were significant in patients with pre-aflibercept best-corrected visual acuity less than 1.0 logMAR but were not significant in patients with best-corrected visual acuity more than 1.0 logMAR. Conclusions Switching to aflibercept in DME patients with an unsatisfactory response to previous anti-VEGF injections provided acceptable short-term visual and retinal architectural improvement.

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A Hospital Based Study Regarding Awareness of Association Between Glycosylated Haemoglobin and Severity of Diabetic Retinopathy in Type 2 Diabetic Individuals

Cited by 10 publications

References 11 publications

Early changes in pulmonary function and intrarenal haemodynamics and the correlation between these sets of parameters in patients with T2DM

Early changes in pulmonary function and intrarenal haemodynamics and the correlation between these sets of parameters in patients with T2DM

Baseline Diabetes Knowledge Assessment Amongst Adults With Type 1 and Type 2 Diabetes Receiving Eye Care at a Tertiary Ophthalmic Centre in Canada

Switching to Aflibercept in Diabetic Macular Edema after Unsatisfactory Response to Other Anti-vascular Endothelial Growth Factor Drugs

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