A hot water extract of turmeric (<i>Curcuma longa</i>) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production

Uchio, Ryusei; Higashi, Yohei; Kohama, Yoshimitsu; Kawasaki, Kengo; Hirao, Takashi; Muroyama, Koutarou; Murosaki, Shinji

doi:10.1017/jns.2016.43

Cited by 46 publications

(49 citation statements)

References 52 publications

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“…Palmitate significantly enhanced intracellular RDS production in HepG2 cells, whereas this was almost completely prevented by TENE ( Figure 4). On line with this result, a hot water extract of turmeric inhibits ethanol-induced liver injury by inhibiting hepatic oxidative stress and production of inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (OL)-6 (Uchio et al, 2017). On addition, turmeric extract and its active compound curcumin also exhibited hepatoprotective activity against carbon tetrachloride-induced injury in mice by suppressing hepatic oxidative stress (Lee et al, 2016).…”

Section: Effects Of Tene On Palmitate-induced Lipid Accumulation and mentioning

confidence: 80%

“…The beneficial effects of turmeric extract on hepatic disease have also been demonstrated in the chemical-induced liver injury in which administration of turmeric extract was associated with a significant reduction in the hepatic oxidative states (Uchio et al, 2017;Lee et al, 2016). A dietary supplement containing turmeric extract also prevented the development of nonalcoholic fatty liver disease (NAFLD) by modulating the levels of serum glucose and leptin in patients with NAFLD (Navekar et al, 2017).…”

Section: Effects Of Tene On Palmitate-induced Lipid Accumulation and mentioning

confidence: 97%

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Anti-adipogenic effect of a turmeric extract-loaded nanoemulsion in 3T3-L1 preadipocytes and high fat diet-fed mice

et al. 2019

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We investigated the effects of a turmeric extract-loaded nanoemulsion (TENE) on lipid accumulation in 3T3-L1 adipocytes and in mice fed a high fat diet (HFD). The accumulation of intracellular lipid in 3T3-L1 adipocytes was significantly inhibited by TENE, according to Dil red D and Nile Red staining. This inhibitory effect of TENE on adipocyte differentiation was associated with lower expression levels of the adipocyte-specific genes, PPARγ, aP2, and C/EBPα. On HepG2 hepatocytes, TENE attenuated palmitate-induced intracellular accumulation of lipid and RDS. On mice fed a HFD, TENE significantly reduced the serum levels of total cholesterol, triglycerides, and LDL and increased HDL levels. These effects of TENE were accompanied by reductions in the expression of PPARγ, aP2, and C/EBPα in adipose tissue and smaller epididymal adipocytes. These results suggest that TENE inhibits adipogenesis by reducing expression of adipogenic transcription factors, thereby substantiating the potential to ameliorate metabolic disorders related to obesity.

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Section: Effects Of Tene On Palmitate-induced Lipid Accumulation and mentioning

confidence: 80%

Section: Effects Of Tene On Palmitate-induced Lipid Accumulation and mentioning

confidence: 97%

Anti-adipogenic effect of a turmeric extract-loaded nanoemulsion in 3T3-L1 preadipocytes and high fat diet-fed mice

et al. 2019

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“…26 We recently reported that a hot water extract of C longa (WEC) suppresses acute ethanol-induced liver injury by inhibiting hepatic oxidative stress and inflammatory cytokine production. 27 Topical application of an extract of C longa was also shown to improve skin conditions 28 ; however, the influence of intake of WEC on human skin conditions has not yet been clarified.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…For example, aqueous extracts of C longa have been reported to exhibit antioxidant and anti‐inflammatory activities, to promote corneal wound healing, and to have antidepressant and an anticancer effects . We recently reported that a hot water extract of C longa (WEC) suppresses acute ethanol‐induced liver injury by inhibiting hepatic oxidative stress and inflammatory cytokine production . Topical application of an extract of C longa was also shown to improve skin conditions; however, the influence of intake of WEC on human skin conditions has not yet been clarified.…”

Section: Introductionmentioning

confidence: 99%

Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double‐blind, placebo‐controlled trial

Asada¹,

Ohara²,

Muroyama³

et al. 2019

J of Cosmetic Dermatology

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Summary Background Curcuma longa has been reported to have anti‐inflammatory effects. Skin inflammation impairs skin functions. Objectives Our aim was to investigate the effect of a hot water extract of C longa (WEC) on skin conditions in cell studies using keratinocytes and in clinical trials. Methods We measured proinflammatory cytokine levels in ultraviolet B‐irradiated keratinocytes in the presence or absence of WEC. The effects of WEC on hyaluronan production in keratinocytes were also determined. In a randomized, double‐blind, placebo‐controlled trial, 47 healthy participants were assigned to 8‐week intervention groups with daily intakes of WEC with or without curcumin or a placebo. The water content and transepidermal water loss in the face and minimal erythema dose on the back after ultraviolet B irradiation were evaluated every 4 weeks. Results Hot water extract of C longa significantly inhibited increases in ultraviolet B‐induced tumor necrosis factor α and interleukin 1β at the mRNA and protein levels. WEC also significantly increased hyaluronan production from nonstimulated keratinocytes. In the randomized, double‐blind, placebo‐controlled trial, increases from baseline in the water content of the face were significantly greater at weeks 4 and 8 in the WEC group, but not in the WEC + curcumin group, than in the placebo group. There were no significant differences in transepidermal water loss and minimal erythema dose among the groups. Conclusions The cell studies confirmed that WEC has anti‐inflammatory effects and augments hyaluronan production in the skin. The results of clinical trials suggest that WEC may be useful for moisturizing facial skin. Trial registration UMIN Clinical Trials Registry 000028510. Retrospectively registered.

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“…Several therapeutic and pharmacologic properties of C. longa have recently been reported; antioxidant activity [13][14][15], cardiovascular and anti-diabetic effects [16][17][18] inflammatory and edematic disorders [19][20][21], anti-cancer [22,23], [26,27], anti-microbial [24][25], hepatoprotection [26,27] protection against Alzheimers [28][29][30], photo protector [12,31]. Although majority of spices and medicinal herbs are commonly presumed to be safe, adverse effects occasionally arise after the consumption of herbal products.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

Alafiatayo

Song

Ahmad

et al. 2019

Preprint

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Curcuma longa L. is a rhizome plant often used as traditional medicinal preparations in Southeast Asia. The dried powder is commonly known as cure-all herbal medicine with a wider spectrum of pharmaceutical activities. In spite of the widely reported therapeutic applications of C. longa, research on its safety and teratogenic effects on zebrafish embryos and larvae is still limited. Hence, this research was aimed to assess the toxicity of C. longa extract on zebrafish. Using a reflux flask, methanol extract of C. longa was extracted and the identification and quantification of total flavonoids were carried out with HPLC. Twelve fertilized embryos were selected to test the embryotoxicity and teratogenicity at different concentration points. The embryos were exposed to the extract in the E3M medium while the control was only exposed to E3M and different developmental endpoints were recorded with the therapeutic index calculated using the ratio of LC50/EC50. C. longa extract was detected to be highly rich in flavonoids with catechin, epicatechin and naringenin as the 3 most abundant with concentrations of 3,531.34, 688.70 and 523.83μg/mL respectively. The toxicity effects were discovered to be dose-dependent at dosage above 62.50μg/mL, while at 125.0μg/mL, mortality of embryos was observed and physical body deformities of larvae was recorded among the hatched embryos at higher concentrations. Teratogenic effect of the extract was severe at higher concentrations producing physical body deformities such as kink tail, bend trunk, enlarged yolk sac edema. Finally, the Therapeutic Index (TI) values calculated were approximately same for different concentration points tested. Overall, the result revealed that plants having therapeutic potential could also pose threats when consumed at higher doses especially on the embryos. Therefore, detailed toxicity analysis should be carried out on medicinal plants to ascertain their safety on the embryos and its development. Abbreviations:DMSO, dimethyl sulfoxide; HPLC, high performance liquid chromatography; OECD, organisation for economic cooperation and development; FET, fish embryo acute toxicity test; hpf, hour of post fertilization.

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A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production

Cited by 46 publications

References 52 publications

Anti-adipogenic effect of a turmeric extract-loaded nanoemulsion in 3T3-L1 preadipocytes and high fat diet-fed mice

Anti-adipogenic effect of a turmeric extract-loaded nanoemulsion in 3T3-L1 preadipocytes and high fat diet-fed mice

Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double‐blind, placebo‐controlled trial

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

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