A How-To Compendium for GammaPod Treatments, Clinical Workflow, and Clinical Program at an Early Adopting Institution

Zhang-Velten, Elizabeth; Zhang, You; Radpour, Sepeadeh; Gu, Xuejun; Kim, D. Nathan; Alluri, Prasanna; Nwachukwu, Chika; Chiu, Tsuicheng; Lu, Weiguo; Parsons, David; Tan, Jun; Gillespie, Jennifer Z.; Stevenson, Stella; Choy, Hak; Timmerman, Robert; Rahimi, Asal

doi:10.1016/j.prro.2022.01.006

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Other modalities could provide advantages in this pathway, such as GammaPod (Xcision Medical Systems, LLC, Columbia, MD, USA), a device dedicated for stereotactic radiation therapy of BC, with breast immobilization, real-time imaging, and highly-conformal dosimetry [45]. In conclusion, both the neoadjuvant and the definitive settings seem to be promising clinical scenarios for SBRT management of this disease presentation.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Radiotherapy in Early-Stage Breast Cancer in Neoadjuvant and Exclusive Settings: A Systematic Review

Piras¹,

Sanfratello²,

Boldrini

et al. 2022

Oncol Res Treat

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Introduction Breast cancer (BC) is one of the most common tumours, better screening policies and multidisciplinary approach allow personalised treatment. Radiotherapy (RT) plays a central role in the multimodal approach in BC, and recent evidence have shown the non-inferiority of hypofractionated treatments. The aim of this study is to describe the feasibility and validity of stereotactic RT (SBRT) in BC in neoadjuvant and exclusive setting. Methods A Pubmed/MEDLINE and Embase systematic review was conducted to assess the role of radiomics in BC. The search strategy was “breast [All Fields] AND "stereotactic" [All Fields] AND "radiotherapy" [All Fields])” and only original articles referred to BC in humans in the English language were considered. Results A total of 2149 studies were obtained using the mentioned search strategy on Pubmed and Embase. After the complete selection process, a total of 12 papers were considered eligible for the analysis of the results. SBRT in BC was described in 8 studies regarding neoadjuvant approach and 4 papers regarding exclusive approach. Conclusions Relative low toxicity rates; the reduced treatment volumes in the neoadjuvant setting and the possibility to replace surgery when not feasible in exclusive setting, resulted to be main advantages for SBRT in BC. Current evidence showed as both the neoadjuvant and the definitive settings seem to be promising clinical scenarios for SBRT especially for EBC.

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Section: Discussionmentioning

confidence: 99%

Stereotactic Radiotherapy in Early-Stage Breast Cancer in Neoadjuvant and Exclusive Settings: A Systematic Review

Piras¹,

Sanfratello²,

Boldrini

et al. 2022

Oncol Res Treat

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“…In particular, the traditional whole breast irradiation has been replaced in some selected cases by partial breast irradiation, which has the possibility of intraoperative administration [75]. In addition, several modalities have been designed that permit the reduction of dose fractionation [76], up to the administration of a single dose within clinical trials [77].…”

Section: The Rationale Of Margins Evaluationmentioning

confidence: 99%

Updates and Debate Concerning Margin Adequacy and Management following Breast-Conserving Surgery

Bertozzi¹,

Londero²,

Nanez³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Objective: Breast-conserving surgery (BCS) experienced a significant surge during the last decades due to the increase of early breast cancer detection. Central to the discussion is margin adequacy which represents one of the most significant predictive factors for local relapse. This paper aims to shed light on the problem of margins in breast surgery. Mechanism: We performed a systematic narrative review of the literature by conducting a search using Medline/PubMed, Scopus, and Embase. The following keywords were considered: "breast-conserving surgery" AND "margins"/"margin". Findings in Brief: In the case of invasive breast cancer, "no ink on tumor" can be considered an adequate margin, while for ductal carcinoma in situ (DCIS), a distance of 2 mm from tumor should be obtained. Many novel tools have been developed based both on the latest radiological imaging techniques and on the tissue expression of certain markers, with the aim of precise navigation of tumor excision and intraoperative evaluation of cavity excision margins. Oncoplastic surgery can be considered oncologically safe while improving the cosmetic outcome and patients' quality of life. The appropriate use of adjuvant treatments in the context of a multidisciplinary and personalized management of breast cancer is the only means to omit a second intervention in some carefully selected cases. Conclusions: Debate still exists concerning the definition of adequate clear margin following BCS for DCIS. Further studies are required to better assess multimodal treatment approaches in this condition.

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Definitive ablative stereotactic partial breast irradiation in early stage inoperable breast cancer

Miljanic,

Nwachukwu,

Rahimi

2023

J Cancer Res Clin Oncol

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A How-To Compendium for GammaPod Treatments, Clinical Workflow, and Clinical Program at an Early Adopting Institution

Cited by 3 publications

References 17 publications

Stereotactic Radiotherapy in Early-Stage Breast Cancer in Neoadjuvant and Exclusive Settings: A Systematic Review

Stereotactic Radiotherapy in Early-Stage Breast Cancer in Neoadjuvant and Exclusive Settings: A Systematic Review

Updates and Debate Concerning Margin Adequacy and Management following Breast-Conserving Surgery

Definitive ablative stereotactic partial breast irradiation in early stage inoperable breast cancer

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