2022
DOI: 10.1016/j.celrep.2022.111046
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A human adipose tissue cell-type transcriptome atlas

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Cited by 49 publications
(46 citation statements)
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“…Yet another recent section addresses Adipose tissues. 78 In addition to the updates to the HPA database, the HPA workflow and antibodies have been utilized for several major research studies, including several projects linked to the COVID-19 pandemics 79−82 and efforts for advanced imaging. One example is 3D imaging of sympathetic innervations, leading to further understanding of nonalcoholic fatty liver disease.…”
Section: ■ Highlights From the Antibody Pillar/human Protein Atlasmentioning
confidence: 99%
“…Yet another recent section addresses Adipose tissues. 78 In addition to the updates to the HPA database, the HPA workflow and antibodies have been utilized for several major research studies, including several projects linked to the COVID-19 pandemics 79−82 and efforts for advanced imaging. One example is 3D imaging of sympathetic innervations, leading to further understanding of nonalcoholic fatty liver disease.…”
Section: ■ Highlights From the Antibody Pillar/human Protein Atlasmentioning
confidence: 99%
“…Differences between this study and previous studies could have arisen due to the fact that a greater number of healthy nuclei was analysed in our study or due to the differences in transcriptomics methods (single cell vs single nucleus approaches). While single cell transcriptomics generally capture more RNA per cell, including stable transcripts in the cytoplasm that might not be present in the nucleus, single nucleus transcriptomics enables the capture of a wider variety of cells, including cells that are hard to capture with single cell techniques due to the buoyancy or larger size of cells[26, 27].…”
Section: Discussionmentioning
confidence: 99%
“…To identify stomach cell type-enriched transcriptome profiles, we conducted an analysis based on our previously developed method (Butler et al, 2016;Dusart et al, 2019;Norreen-Thorsen et al, 2022), using human stomach bulk RNAseq data (N=359) from Genotype-Tissue Expression (GTEx) portal V8 (https://gtexportal.org) (Consortium, 2015). Each sample was unfractionated and thus contained a mix of cell types (Figure 1 A.i), which contribute differing proportions of transcripts that are measured by RNAseq (Figure 1 A.ii).…”
Section: Cell Type Reference Transcripts Correlate Across Unfractiona...mentioning
confidence: 99%