A Human ‘D-like’ Antibody

Levine, Philip; Celano, Marino; Wallace, John; Sanger, Ruth

doi:10.1038/198596a0

Cited by 69 publications

(23 citation statements)

References 6 publications

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“…Tests on 10,025 Finnish donors show the antithetical relationship of anti-Nea (proposed name anti-LWb) and anti-LW made by LW3 people (proposed name anti-LWa). Tests on families of previously reported LW3 propositi and of LW(a-b+) Finnish donors support the hypothesis that Ne* (L Wh) is an allele at the L W locus which when homozygous produces the phenotype once [5][6][7]. The history and notation of LW is complex since the rare LW-negative pheno type can reflect a true genetical state or a transient acquired condition found during illness and antibody formation [for reviews see references 8-10].…”

mentioning

confidence: 62%

“…The first clue to a difference between the two antibodies was observed by Fisk and Foord [3] in 1942, who found that the cells of all newborn babies, whether Rh positive or negative as defined by human anti-Rh, were positive with guin ea-pig anti-Rh. Subsequent work, initiated by Murray and Clark [4] [5][6][7]. The history and notation of LW is complex since the rare LW-negative pheno type can reflect a true genetical state or a transient acquired condition found during illness and antibody formation [for reviews see references [8][9][10].…”

mentioning

confidence: 99%

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A ‘New’ Allele Giving Further Insight into the LW Blood Group System

Sistonen¹,

Tippett²

1982

Vox Sanguinis

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Ne^a red cell antigen present in 6% of Finnish people but in less than 1% of other Europeans tested, is shown to be part of the LW system. Tests on 10,025 Finnish donors show the antithetical relationship of anti-Ne^a (proposed name anti-LW^b) and anti- LW made by LW(3) people (proposed name anti-LW^a). Tests on families of previously reported LW(3) propositi and of LW(a-b+) Finnish donors support the hypothesis that Ne^(a) (LW^b) is an allele at the LW locus which when homozygous produces the phenotype once called LW(3).

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confidence: 62%

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confidence: 99%

A ‘New’ Allele Giving Further Insight into the LW Blood Group System

Sistonen¹,

Tippett²

1982

Vox Sanguinis

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“…But it was in 1962 that Levine et al [8] found the first human blood sample that failed to react with that antibody, and the following year, Levine et al [9] discovered the first two cases of anti-LW in D-positive individuals. A further case of anti-LW was then reported by Swanson and Matson [20] in 1964.…”

Section: Introductionmentioning

confidence: 99%

‘Cold’ IgG Autologous Anti-LW

Perrault¹

1973

Vox Sanguinis

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In the routine antibody screening of 45,000 blood samples, 10 cases of coldreacting, autologous anti-LW were discovered, using a low-ionic strength-polybrene Auto-Analyzer. Two of these were shown to belong to the IgG, and one to the IgM class. The others were suspected to belong to the IgG class. An immune anti-LW (from a Dpositive, LW-negative patient) was used for comparison with the cold, ‘naturally-occurring’ anti-LW, and further comparisons were made with anti-D. DEAE fractionation shows a much greater heterogeneity for anti-LW than for anti-D, but iso-electrofocusing of the main IgG fraction shows similar iso-electric points: 8.8 and 8.9 for anti-D and anti-LW, respectively. However, the autologous IgG anti-LW showed an iso-electric point of 8.2, representing a different relationship to the bulk of IgG. The ability for immune anti-LW to discriminate between Rh-positive and negative cells was far greater with the low-ionic strength-polybrene Auto-Analyzer than with the bromelin-methyl cellulose method. In manual testing, the DEAE fractions showed such a discriminating ability only with the IgM containing fractions.

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“…Only after 1963 Levine et al 8 proposed that the heteroantibody of rabbits should be named anti-LW (a tribute to Landsteiner and Wiener) and the human should be named anti-D. The Rh name resulted from the LW antigen.…”

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confidence: 99%

Bases moleculares do sistema Rh e suas aplicações em obstetrícia e medicina transfusional

Nardozza¹,

Szulman²,

Barreto³

et al. 2010

Rev. Assoc. Med. Bras.

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The Rh system is the most polymorphic and immunogenic of all blood group systems. Currently, over 49 antigens have been identified, among which the five main antigens are D, C, c, E, e. Knowledge of the Rh system's molecular basis, since its first cloning 17 years ago, has allowed for an understanding of the mechanism of Rh-negative phenotype and of the variants of antigens RHD and RHCE. Deletions, gene rearrangements and insertions are the main mutations. In Caucasians, the primary mechanism of Rh-negative phenotype is the complete RHD gene deletion, whereas in Afrodescendant it is the presence of pseudogene RHDø and hybrid gene RHD-CE (4-7)-D. The authors analyzed the structure of the Rh complex in red cells, the molecular basis of the Rh system, mechanisms of RHD negativity and weak and partial RHD expressions.

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A Human ‘D-like’ Antibody

Cited by 69 publications

References 6 publications

A ‘New’ Allele Giving Further Insight into the LW Blood Group System

A ‘New’ Allele Giving Further Insight into the LW Blood Group System

‘Cold’ IgG Autologous Anti-LW

Bases moleculares do sistema Rh e suas aplicações em obstetrícia e medicina transfusional

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