1997
DOI: 10.1002/(sici)1099-1573(199709)11:6<433::aid-ptr122>3.0.co;2-#
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A human immunodeficiency virus protease inhibitory substance from Swietenia mahagoni

Abstract: For the purpose of finding anti‐HIV agents from natural sources, various plant extracts were screened for their inhibitory activity against HIV‐protease, an enzyme essential for viral proliferation. By bioassay‐directed fractionation of the methanol extract of Swietenia mahagoni (bark) which had shown inhibitory activity against this enzyme, we isolated and identified chlorogenic acid methyl ester as a inhibitory substance, its 50% inhibitory concentration being less than 40 μg/ml. © 1997 John Wiley & Sons, Lt… Show more

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Cited by 18 publications
(11 citation statements)
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“…The extract of this plant showed ameliorative effects on diabetic mice [6], antimicrobial properties [7,8], platelet aggregation inhibitory [9], and anti-human immunodeficiency virus (HIV) activities [10]. Chlorogenic acid from the methanol extract of this plant displayed human immunodeficiency virus protease inhibitory activity [11]. Previous phytochemical investigations on this species led to isolation and identification of more than 45 limonoids belonging to the structural classes andirobin, gendunin, mexicanolide and phragmalin, triterpens, tetranortriterpenes, and chlorogenic acid [4,5,9,11,12].…”
Section: Introductionsupporting
confidence: 92%
See 1 more Smart Citation
“…The extract of this plant showed ameliorative effects on diabetic mice [6], antimicrobial properties [7,8], platelet aggregation inhibitory [9], and anti-human immunodeficiency virus (HIV) activities [10]. Chlorogenic acid from the methanol extract of this plant displayed human immunodeficiency virus protease inhibitory activity [11]. Previous phytochemical investigations on this species led to isolation and identification of more than 45 limonoids belonging to the structural classes andirobin, gendunin, mexicanolide and phragmalin, triterpens, tetranortriterpenes, and chlorogenic acid [4,5,9,11,12].…”
Section: Introductionsupporting
confidence: 92%
“…Chlorogenic acid from the methanol extract of this plant displayed human immunodeficiency virus protease inhibitory activity [11]. Previous phytochemical investigations on this species led to isolation and identification of more than 45 limonoids belonging to the structural classes andirobin, gendunin, mexicanolide and phragmalin, triterpens, tetranortriterpenes, and chlorogenic acid [4,5,9,11,12]. As a part of our ongoing phytochemical and bioactivity studies on Bangladeshi plants [13][14][15][16][17][18], we now report on the isolation, identification, and antibacterial properties of two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2), the latter being a new natural product, from Swietenia mahagoni against a number of multiple-drug-resistant (MDR) bacterial strains.…”
Section: Introductionmentioning
confidence: 99%
“…These transformation products can be mistakenly treated as new plant components or can lead to erroneous quantitative estimations of plant composition when some or all compounds formed from trans-5-CQA during its extraction really exist in the examined plant and the trans-5-CQA transformation process only increases their amount. Methyl ester of trans-5-CQA is the example of CQA derivative whose presence or amount in plants can be disputable as it was identified in methanolic extract of Swietenia mahagoni (Matsuse et al, 1997), Hypericum montbretii (Demirkiran et al, 2013) (Ma et al, 2003). In this context, the challenge in CQAs analysis in plants is to obtain an extract which does not contain CQAs transformation products and whose composition would reflect the true concentration of CQAs and their natural derivatives in plants.…”
Section: Introductionmentioning
confidence: 99%
“…The results obtained by the different techniques were significantly variable, offering diverse potential according to the types of metabolites present in each plant species (Figure 1). For the DPPH, ABTS and FRAP assays, the species S. macrophylla had the highest activity followed by S. mahagoni, which was in accordance with previous reports (Falah et al, 2008;Matsuse et al, 1997;Rahman et al, 2014;Sahgal et al, 2009). In particular, for the DPPH and ABTS assays for both species, the latest assay showed higher values, which could be due to the low selectivity of the radical ABTS, which reacted with hydroxylated compounds independently of its antioxidant potential (Roginsky and Lissi, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…In the case of S. mahagoni the antagonist activity of the plateletactivating factor was determined (Kadota et al, 1989). In addition, methyl esters of the cholinergic acid with a high antioxidant activity were reported for this species (Matsuse et al, 1997). Similarly, the in vitro antioxidant potential of the methanol extract of seeds of S. mahagoni was determined using different techniques, with a positive effect to scavenge free radicals and inhibit the enzyme xanthine oxidase, responsible for generating ROS (Sahgal et al, 2009).…”
Section: Introductionmentioning
confidence: 99%