A Human Model of Allergic Conjunctivitis

Stegman, Robert L; Miller, David L.

doi:10.1001/archopht.1975.01010020978008

Cited by 20 publications

(2 citation statements)

References 10 publications

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“…However, there was a time lag between administra tion of the drug and onset of inhibition. This is in accordance with other experimental [Church and Miller, 1978] and clinical findings [Stegman and Miller, 1975],…”

Section: Discussionsupporting

confidence: 94%

Passive Anaphylaxis in Rat Conjunctiva and Topical Effects of Antiallergic Agents Hypersensitivity in Conjunctiva and Drug Efficacy

Iso¹,

Nakajima²,

Suda³

et al. 1980

Ophthalmic Res

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Homologous passive anaphylactic reaction mediated by a reaginic antibody was caused in rat conjunctiva and the effects of several drugs on this reaction were examined by estimating the leakage of dye in the tissue as a parameter of the increased vascular permeability during anaphylaxis. In this model, topical application of disodium cromoglycate did not produce any effect, while given intravenously marked inhibition was elicited. Other antiallergic drugs such as dexamethasone, mepyramine, epinephrine and glycyrrhizin were effective topically as well as systemically. On the other hand, indomethacin given orally and topically tended to enhance the reaction. Present results suggest that this model may be useful as a convenient method for screening of topical antiallergic drugs on the immediate ocular hypersensitivity reaction.

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Section: Discussionsupporting

confidence: 94%

Passive Anaphylaxis in Rat Conjunctiva and Topical Effects of Antiallergic Agents Hypersensitivity in Conjunctiva and Drug Efficacy

Iso¹,

Nakajima²,

Suda³

et al. 1980

Ophthalmic Res

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“…The average amount found was 2.92 mgJml (Stegman (1975), using refractometer, found 3-7 mgiml). The distribution is seen in Fig.…”

Section: Protein and Haemolacriamentioning

confidence: 90%

Microscopically and Chemically Detected Haemolacria

Norn

1977

Acta Ophthalmologica

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Two methods have been developed for the detection of occult haemolacria (occult blood in tears): 1) Microscopy of conjunctival fluid aspirated by means of the quantitative pipette method. 2) Chemical stix method employed on a sample of conjunctival fluid transferred to cotton-wool plug. Double samples from 306 eyes were subjected to microscopy, and chemical tests were performed on samples from 303 other eyes. Microscopy has been found to disclose occult blood in 13 per cent of normals (2 100 erythro-cytesi3.1 mm* in 3 per cent of normals), while blood is detected chemically in 3 per cent. Occult blood is most frequently found in cases of acute infectious conjunctivitis (65 per cent microscopically and 21 per cent chemically), less frequently in subacute and chronic infectious conjunctivitis (26 and 20 per cent respectively). Haemolacria is most frequently seen in relation to neutrophilia (45 per cent), less frequently with lymphocytosis (35 per cent), and even more rarely in the absence of both neutrophilia and lymphocytosis (1 1 per cent). Ciliary congestion is a n unlikely cause of haemolacria. Postoperatively blood is present for two or three days, whereas blood instilled into the conjunctival sac of a normal eye disappears in less than one hour. The protein concentration in tears is raised in association with haemolacria.Read before the Danish Ophthalmological Society October 9, 1976. 132 Microscopically and Chemically Detected Haemolacria

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