A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells

Abstract

We recently demonstrated that human BM cells can be treated in vitro with defined growth factors to induce the rapid generation of myeloid-derived suppressor cells (MDSCs), hereafter defined as BM-MDSCs. Indeed, combination of G-CSF ؉ GM-CSF led to the development of a heterogeneous mixture of immature myeloid cells ranging from myeloblasts to band cells that were able to suppress alloantigen-and mitogen-stimulated T lymphocytes. Here, we further investigate the mechanism of suppression and define the cell subset that is fully responsible for BM-MDSC-mediated immune suppression. This population, which displays the structure and markers of promyelocytes, is however distinct from physiologic promyelocytes that, instead, are devoid of immuosuppressive function.

Increased Myeloid-Derived Suppressor Cells in Gastric Cancer Correlate with Cancer Stage and Plasma S100A8/A9 Proinflammatory Proteins

“…2 ), which was recently described in bone marrow-derived MDSCs, is equivalent to MDSCs present in the blood of patients with stage IV breast cancer (45). These populations display the structure and markers of promyelocytes and are immunosuppressive.…”

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

“…CD34 + MDSC were first isolated from head and neck squamous cell carcinoma (HNSCC) patients due to their high abundance in this tumor (4). Clinical correlation studies in breast, colorectal, pancreatic, esophageal, and gastric cancer patients demonstrated that increased MDSC levels may be an important independent prognostic factor for survival (5,6). For lung cancer patients, MDSC level is negatively correlated with responsiveness to standard chemotherapy (7).…”

Myeloid-derived suppressor cell accumulation in renal cell carcinoma is correlated with CCL2, IL-17 and IL-18 expression in blood and tumors

“…In this study, MDSC subset levels in the peripheral blood of RCC patients vs healthy donors were compared and the results showed that total MDSC, as well as G-MDSC and I-MDSC, are elevated in patients, which is consistent with several other studies. 22,23 The levels of M-MDSC did not change significantly, probably due to its lowest subset proportion or its potential differentiation into G-MDSC or TAMs. 24,25 Total MDSC, G-MDSC and I-MDSC in the peripheral blood of RCC patients correlated with increasing tumor grade.…”