A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice

Criscio, Michela Di; Lodahl, Jennifer Ekholm; Stamatakis, Antonios; Kitraki, Efthimia; Bakoyiannis, Ioannis; Repouskou, Anastasia; Bornehag, Carl-Gustaf; Gennings, Chris; Lupu, Diana; Rüegg, Joëlle

doi:10.1016/j.chemosphere.2022.137633

Cited by 4 publications

(3 citation statements)

References 73 publications

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“…CRHR [90,76], as well as hippocampal and hypothalamic FKBP1, an important regulator of glucocorticoid receptor expression in the brain [91].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Consequently, expression of CRH receptor (CRHR) and GR were dysregulated in the limbic system, hypothalamic PVN, pituitary, and adrenal gland 70 . Moreover, a mixture of phthalates, pesticides and BPA have been shown to induce hypomethylation and altered transcription of hippocampal HPA-related genes: MR and CRHR 76 90 , as well as hippocampal and hypothalamic FKBP1, an important regulator of glucocorticoid receptor expression in the brain 91 .…”

Section: Disruption Of Endocrine Circuitsmentioning

confidence: 99%

See 1 more Smart Citation

Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

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Endocrine-disrupting chemicals (EDCs) are exogenous substances known to interfere with endocrine homeostasis and promote adverse health outcomes. Their impact on the adrenal cortex, corticosteroids and their physiological role in the organism has not yet been sufficiently elucidated. In this review, we collect experimental and epidemiological evidence on adrenal disruption by relevant endocrine disruptors. In vitro data suggest significant alterations of gene expression, cell signalling, steroid production, steroid distribution, and action. Additionally, morphological studies revealed disturbances in tissue organization and development, local inflammation, and zone-specific hyperplasia. Finally, endocrine circuits, such as the hypothalamic-pituitary-adrenal axis, might be affected by EDCs. Many questions regarding the detection of steroidogenesis disruption and the effects of combined toxicity remain unanswered. Not only due to the diverse mode of action of adrenal steroids and their implication in many common diseases, there is no doubt that further research on endocrine disruption of the adrenocortical system is needed.

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“…CRHR [90,76], as well as hippocampal and hypothalamic FKBP1, an important regulator of glucocorticoid receptor expression in the brain [91].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Disruption Of Endocrine Circuitsmentioning

confidence: 99%

Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

View full text Add to dashboard Cite

show abstract

“…Like prenatal stress, there is evidence that EDCs can cause epigenetic modifications which result in intergenerational changes to the function of the HPA axis [78][79][80][81] . Additionally, prenatal exposure to a mixture of EDCs alters the methylation status of the CRF1 receptor gene in the hippocampus of adult mice in a manner correlated with hyperactive behavioral changes 82 .…”

Section: Prenatal Endocrine Disrupting Chemical Exposure and The Hypo...mentioning

confidence: 99%

Prenatal Stress and Endo-crine Disrupting Chemical Exposure: Hypothalamic-Pituitary-Adrenal Axis Dysregulation as a Mecha-nism for the Health Conse-quences of Both

Hall

Mercugliano

Conti

2023

MRAJ

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During the past several decades there has been increasing attention to the risks of exposure to endocrine disrupting chemicals, agents that mimic or block the effects of endogenous hormones. Previous research demonstrates that there may be critical periods of development where factors such as prenatal stress and endocrine disrupting chemical exposure can result in endocrine system dysregulation which manifests both immediately and later in life. This review describes the types of common endocrine disrupting chemicals and routes of exposure, the structure and functions of the hypothalamic-pituitary-adrenal axis and its role in the physiological response to stress, and highlights the current evidence showing that endocrine disrupting chemicals may alter normal hypothalamic-pituitary-adrenal axis functions. These topics are unified upon discussion of evidence indicating that prenatal endocrine disrupting chemical exposure has many of the same effects as prenatal stress on the hypothalamic-pituitary-adrenal axis, leading to long-term dysregulation of the axis and subsequent alterations in physiological responses to stress. We further suggest that prenatal endocrine disrupting chemical exposure in combination with prenatal stress may result in additive, if not synergistic effects on the hypothalamic-pituitary-adrenal axis-mediated stress response. Finally, we discuss vulnerable populations at an elevated risk for dual stress and endocrine disrupting chemical exposure and emphasize critical areas for future research.

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Priority list of potential endocrine-disrupting chemicals in food chemical contaminants: a docking study and in vitro/epidemiological evidence integration

Ren,

Jin,

et al. 2023

SAR and QSAR in Environmental Research

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A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice

Cited by 4 publications

References 73 publications

Endocrine Disruptors: Focus on the Adrenal Cortex

Endocrine Disruptors: Focus on the Adrenal Cortex

Prenatal Stress and Endo-crine Disrupting Chemical Exposure: Hypothalamic-Pituitary-Adrenal Axis Dysregulation as a Mecha-nism for the Health Conse-quences of Both

Priority list of potential endocrine-disrupting chemicals in food chemical contaminants: a docking study and in vitro/epidemiological evidence integration

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