A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

Arshad, Rabia; Tabish, Tanveer A.; Kiani, Maria Hassan; Ibrahim, Ibrahim M.; Shahnaz, Gul; Rahdar, Abbas; Kang, Misook; Pandey, Sadanand

doi:10.3390/nano11051086

Cited by 56 publications

(30 citation statements)

References 41 publications

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“…Hyaluronic Acid Hyaluronic acid (HA) is another FDA-approved natural bioadhesive polymer that has been widely investigated for constructing various functional delivery vehicles. Especially due to its mucoadhesive properties, HA can enhance the bioavailability of carried substances through various delivery routes, such as ocular, nasal, and pulmonary administration routes [78,79]. HA-based nanoparticles or nanoconjugates are considered valuable candidates for drug delivery in cancer and atherosclerosis therapy [80].…”

Section: Pullulanmentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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Section: Pullulanmentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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“…The ‘nano-gels’ and similar materials are of interest especially for medical and biomedical applications, often as smart drug-release systems. Examples include polyacrylate copolymer nano-gel particles serving as drug vehicle in cancer therapy [ 37 ], pH-sensitive drug-releasing micelles [ 38 ], or self-nanoemulsifying drug delivery systems (SNEDDS—nano-droplets) [ 39 ]. Also the opposite function of nano-gels was explored, namely the selective removal of specific molecules (e.g., dyes) from the surrounding solution [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…Finally, highly modified derivatives of the studied nanocomposites could be the basis of nano-gel particles, whose applications as drug-release systems, dermal implants etc. were discussed further above (analogy to [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]).…”

Section: Introductionmentioning

confidence: 99%

Novel Tough and Transparent Ultra-Extensible Nanocomposite Elastomers Based on Poly(2-methoxyethylacrylate) and Their Switching between Plasto-Elasticity and Viscoelasticity

et al. 2021

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Novel stiff, tough, highly transparent and ultra-extensible self-assembled nanocomposite elastomers based on poly(2-methoxyethylacrylate) (polyMEA) were synthesized. The materials are physically crosslinked by small in-situ-formed silica nanospheres, sized 3–5 nm, which proved to be a very efficient macro-crosslinker in the self-assembled network architecture. Very high values of yield stress (2.3 MPa), tensile strength (3.0 MPa), and modulus (typically 10 MPa), were achieved in combination with ultra-extensibility: the stiffest sample was breaking at 1610% of elongation. Related nanocomposites doubly filled with nano-silica and clay nano-platelets were also prepared, which displayed interesting synergy effects of the fillers at some compositions. All the nanocomposites exhibit ‘plasto-elastic’ tensile behaviour in the ‘as prepared’ state: they display considerable energy absorption (and also ‘necking’ like plastics), but at the same time a large but not complete (50%) retraction of deformation. However, after the first large tensile deformation, the materials irreversibly switch to ‘real elastomeric’ tensile behaviour (with some creep). The initial ‘plasto-elastic’ stretching thus causes an internal rearrangement. The studied materials, which additionally are valuable due to their high transparency, could be of application interest as advanced structural materials in soft robotics, in implant technology, or in regenerative medicine. The presented study focuses on structure-property relationships, and on their effects on physical properties, especially on the complex tensile, elastic and viscoelastic behaviour of the polyMEA nanocomposites.

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“…In recent decades, industrial applications of polymers and polymer composites have seen an exponential rise in different areas of our life, including pharmaceutical packaging, consumer goods, medical devices, food and cosmetic packaging, etc. Nowadays, the medical devices used for implant replacement are mostly fabricated with ultra-high molecular weight polyethylene (UHMWPE) and/or its carbon-based composites [ 1 , 2 , 3 ]. UHMWPE is the material of choice for orthopedic industrial applications and medical devices that are made of this industrial scale polymeric biomaterial are usually treated with high energy radiation such as gamma, e-beams, or X-rays for sterilization [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Simulation of Light Distribution in Gamma Irradiated UHMWPE Using Monte Carlo Model for Light (MCML) Transport in Turbid Media: Analysis for Industrial Scale Biomaterial Modifications

et al. 2021

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(1) Background: This study investigated the miscibility of carbon-based fillers within industrial scale polymers for the preparation of superior quality polymer composites. It focuses on finding the light distribution in gamma irradiated ultra-high molecular weight polyethylene (UHMWPE). (2) Methods: The Kubleka–Munk model (KMM) was used to extract the optical properties, i.e., absorption coefficients (μa) and scattering coefficients (μs). Samples amounting to 30 kGy and 100 kGy of irradiated (in the open air) UHMWPE from 630 nm to 800 nm were used for this purpose. Moreover, theoretical validation of experimental results was performed while using extracted optical properties as inputs for the Monte Carlo model of light transport (MCML) code. (3) Conclusions: The investigations revealed that there was a significant decrease in absorption and scattering coefficient (μa & μs) values with irradiation, and 30 kGy irradiated samples suffered more compared to 100 kGy irradiated samples. Furthermore, the simulation of light transport for 800 nm showed an increase in penetration depth for UHMWPE after gamma irradiation. The decrease in dimensionless transport albedo μs(μa+μs) from 0.95 to 0.93 was considered responsible for this increase in photon absorption per unit area with irradiation. The report results are of particular importance when considering the light radiation (from 600 nm to 899 nm) for polyethylene modification and/or stabilization via enhancing the polyethylene chain mobility.

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A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

Cited by 56 publications

References 41 publications

Polymer-Based Nanosystems—A Versatile Delivery Approach

Polymer-Based Nanosystems—A Versatile Delivery Approach

Novel Tough and Transparent Ultra-Extensible Nanocomposite Elastomers Based on Poly(2-methoxyethylacrylate) and Their Switching between Plasto-Elasticity and Viscoelasticity

Simulation of Light Distribution in Gamma Irradiated UHMWPE Using Monte Carlo Model for Light (MCML) Transport in Turbid Media: Analysis for Industrial Scale Biomaterial Modifications

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