A Hybrid Approach for a Minimally Invasive Resection of a Gastrointestinal Stromal Tumor

Frey, Sébastien; Maubert, Alexandre; Emmanuel, Benizri

doi:10.26502/jsr.10020067

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2023

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“…The solvent was evaporated by rotary evaporation and the residue purified by column chromatography (PE/EtOAc) to give the desired m -hydroxyaniline derivatives. 32 The products, yields, and R 1 X of the etherification reaction are shown in Table 6.…”

Section: Methodsmentioning

confidence: 99%

Design, synthesis, and biological evaluation of urolithin derivatives as potential phosphodiesterase II inhibitors

Wang

Tang

et al. 2023

Journal of Chemical Research

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Urolithins are the gut microbiota metabolites of ellagitannins which are found in natural plants such as pomegranate, strawberry, and raspberry, and in nuts. Recently, several reports have clarified the underlying mechanism of urolithins in central nervous system inflammation. Therefore, urolithins have become potential therapeutic drug candidate molecules for central nervous system diseases. Derivatives 1–1d, 1–1f, 3–2a, and 3–2b of urolithin A, urolithin B, and methoxyurolithin A were found to have had significant inhibitory activity against phosphodiesterase II with IC50 values of 35.42, 39.96, 25.58, and 13.84 μM, respectively. Herein, we report the design and synthesis of urolithin derivatives along with a biological evaluation of their activity against phosphodiesterase II.

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Section: Methodsmentioning

confidence: 99%