This paper presents the development and validation of five different soft computing methods for flotation performance prediction: (1) two models based on fuzzy logic (Mamdani and Takagi-Sugeno fuzzy inference system) and (2) three models based on artificial neural networks. Copper content in the ore feed, collector dosage in the rougher and the scavenger flotation circuits, slurry pH in the rougher flotation circuit and frother consumption were selected as input parameters to estimate the copper grade and recovery of final concentrate, as well as the copper content in the final tailings of the flotation plant. The training and evaluation of the proposed models were performed on the basis of real process data collected by the multiannual monitoring of industrial flotation plant operation in “Veliki Krivelj Mine”. The results showed that the proposed soft computing-based models well describe the behavior of the industrial flotation plant in a wide range of circumstances. Among the proposed algorithms, artificial neural networks gave the most accurate predictions for the final copper concentrate grade and recovery (R2 = 0.98 and R2 = 0.99, respectively) and copper content in final tailings (R2 = 0.87). At some points, fuzzy logic models are almost equally efficient, but artificial neural networks had lower values for all error functions.