Detection of malignant lung nodules at an early stage may allow for clinical interventions that increase the survival rate of lung cancer patients. Using hybrid deep learning techniques to detect nodules will improve the sensitivity of lung cancer screening and the interpretation speed of lung scans. Accurate detection of lung nodes is an important step in computed tomography (CT) imaging to detect lung cancer. However, it is very difficult to identify strong nodes due to the diversity of lung nodes and the complexity of the surrounding environment. Here, we proposed lung nodule detection and classification with CT images based on hybrid deep learning (LNDC-HDL) techniques. First, we introduce a chaotic bird swarm optimization (CBSO) algorithm for lung nodule segmentation using statistical information. Second, we illustrate an improved Fish Bee (IFB) algorithm for feature extraction and selection. Third, we develop a hybrid classifier i.e. hybrid differential evolution-based neural network (HDE-NN) for tumor prediction and classification. Experimental results have shown that the use of computed tomography, which demonstrates the efficiency and importance of the HDE-NN specific structure for detecting lung nodes on CT scans, increases sensitivity and reduces the number of false positives. The proposed method shows that the benefits of HDE-NN node detection can be reaped by combining clinical practice.