A hybrid microreactor/microwave high-pressure flow system of a novel concept design and its application to the synthesis of silver nanoparticles

Horikoshi, Satoshi; Sumi, Takuya; Serpone, Nick

doi:10.1016/j.cep.2013.07.009

Cited by 50 publications

(37 citation statements)

References 23 publications

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“…It renders the scale up of batch reactors hardly possible, but it is large enough for a rational design of continuous-flow synthesis of metal NPs to achieve high yields (Tu and Liu 2000 ; Groisman and Gedanken 2008 ; Gjuraj et al 2012 ). Moreover, if a tubular reactor is installed in a single-mode microwave cavity, then a homogenous irradiation, and hence uniform heating, can be obtained (Nishioka et al 2011 ; Horikoshi et al 2013 ). The steady and uniform irradiation, while somewhat overlooked until most recently, appears to be vital to achieve a reproducible control of the continuous fabrication of NPs (Nishioka et al 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Rapid continuous microwave-assisted synthesis of silver nanoparticles to achieve very high productivity and full yield: from mechanistic study to optimal fabrication strategy

et al. 2015

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Systematic studies of silver nanoparticle synthesis in a continuous-flow single-mode microwave reactor using polyol process were performed, revealing that the synthesis is exceptionally effective to give very small metal particles at full reaction yield and very high productivity. Inlet concentration of silver nitrate or silver acetate, applied as metal precursors, varied between 10 and 50 mM, and flow rates ranged from 0.635 to 2.5 dm3/h, to give 3–24 s reaction time. Owing to its much higher reactivity, silver acetate was shown to be far superior substrate for the synthesis of small (10–20 nm) spherical silver nanoparticles within a few seconds. Its restricted solubility in ethylene glycol, applied as the solvent and reducing agent, appeared to be vital for effective separation of the stage of particle growth from its nucleation to enable rapid synthesis of small particles in a highly loaded system. This was not possible to obtain using silver nitrate. All the observations could perfectly be explained by a classical LaMer–Dinegar model of NPs’ formation, but taking into account also nonisothermal character of the continuous-flow process and acetate dissolution in the reaction system. The performed studies indicate an optimal strategy for the high-yield fabrication of metal particles using polyol method.

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Section: Introductionmentioning

confidence: 99%

Rapid continuous microwave-assisted synthesis of silver nanoparticles to achieve very high productivity and full yield: from mechanistic study to optimal fabrication strategy

et al. 2015

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“…4 nm in size) have been prepared through a MW assisted device coupled with a flow microreactor [94]. In order to obtain dimensionally homogeneous nanoparticles very efficient mixing of the precursors solutions is needed and was achieved through collisional mixing in a microchannel device.…”

Section: Nanoparticles Synthesismentioning

confidence: 99%

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti

Compagnoni

2016

Chemical Engineering Journal

203

103

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Flow chemistry has been proposed in modern organic chemistry as a mean for process intensification, to improve the control over reaction performance and to achieve higher yield. However, many open issues can be evidenced regarding the true possibility of scale-up, as well as currently lacking information for process design and economical evaluation. This review proposes some recent examples of flow synthesis deepening in particular the scale-up and engineering issues. Required information is evidenced, as well as some transport and kinetic data required for the practical implementation of the results.

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“…Owing to these disadvantages, the progress in the field of microreactor technology offer a series of advantages over conventional methods in terms of smaller particle size, shorter residence time and controllability of the process [11][12][13].Result reported by zhanget al and Chen et al showed that the micro channel reactor having an excellent micromixing property with narrow size distribution and large surface area throughout the reactor [7,9].In addition, microreactor are characterized by their high surface area to volume ratio it enables to reduce heat and mass transfer resistance for the development of uniform nanoparticle in their smallest dimension [12,[14][15][16]. However, the small dimension of microreactor restricts fluids to low Reynolds number (< 2000).…”

Section: Introductionmentioning

confidence: 97%

Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation

Patil

Khairnar

Naik

2015

Chemical Engineering Research and Design

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A hybrid microreactor/microwave high-pressure flow system of a novel concept design and its application to the synthesis of silver nanoparticles

Cited by 50 publications

References 23 publications

Rapid continuous microwave-assisted synthesis of silver nanoparticles to achieve very high productivity and full yield: from mechanistic study to optimal fabrication strategy

Rapid continuous microwave-assisted synthesis of silver nanoparticles to achieve very high productivity and full yield: from mechanistic study to optimal fabrication strategy

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation

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