A hybrid nanoassembly for ultrasound-inducible cytosolic siRNA delivery and cancer sono-gene therapy

Li, Gaigai; Zhang, Yan; Li, Jinbo

doi:10.1016/j.ultsonch.2022.106262

Cited by 11 publications

(9 citation statements)

References 36 publications

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“…To tackle this issue, Li et al developed an acoustic response system to promote the escape of siRNA from lysosomes, which improved the knockdown efficiency of the Bcl‐2 gene and facilitated gene therapy, successfully overcoming the lysosomal dilemma. [ 153 ] In order to further realize the precise individualized treatment of nucleic acid drugs, Shen et al developed a transformable nanosystem made up of gold nanoparticles, Gd compounds, and siRNA to enable real‐time monitoring and display of siRNA accumulation and release in tumors. The siRNA inhibited the expression of the survivin gene, achieving precise diagnosis and individualized treatment of cervical cancer through nucleic acid drugs.…”

Section: Nucleic Acid Therapy Combined With Immunotherapymentioning

confidence: 99%

Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives

Pan,

Xue,

Liang

2024

Advanced NanoBiomed Research

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This review is aiming to systematically elucidate the unique role of nanotechnology in optimizing therapeutic modalities for combinatorial cancer immunotherapy, which enables the synergistic integration of multiple treatment strategies. In particular, nanotechnology has enabled the synergistic combination of immunotherapy with physical therapies, chemotherapy, metal therapy, and nucleic acid therapy. In each combination regimen, nanocarriers play multifaceted roles by achieving targeted codelivery of different therapeutics and optimizing each individual treatment modality. This offers new paradigms to guide precision medicine in cancer treatment. Immunotherapy alone is unlikely to achieve personalized precision medicine for cancer, and new treatment modalities are needed in the future. To overcome technical bottlenecks and realize precise regulation of the tumor microenvironment for personalized cancer treatment, it is crucial to develop novel nanosystems with integrated sensing, targeting, and therapeutic functionalities.

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Section: Nucleic Acid Therapy Combined With Immunotherapymentioning

confidence: 99%

Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives

Pan,

Xue,

Liang

2024

Advanced NanoBiomed Research

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“…The results showed that the nanoparticle could deliver functional luciferase mRNA for translation, while ultrasound irradiation further augmented the translation efficiency (Figure 3c), possibly via facilitating endosome/lysosome escape. [24] Figure 1. Preparation and characterization of fabricated nanoparticles.…”

Section: Cm-rna@ce6/plga Boosting Antigen Presentation Under Ultrasou...mentioning

confidence: 99%

Ultrasound Responsive Nanovaccine Armed with Engineered Cancer Cell Membrane and RNA to Prevent Foreseeable Metastasis

Sun

Zhou

et al. 2023

Advanced Science

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Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti‐tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost tumor immunity and is badly needed. Here, a poly (lactic‐co‐glycolic acid) (PLGA)‐based cancer vaccine of nanoscale is designed, in which engineered tumor cell membrane proteins, mRNAs, and sonosensitizer chlorin e6 (Ce6) are encapsulated at high efficiency. The nanosized vaccine can be efficiently delivered into antigen presentation cells (APCs) in lymph nodes after subcutaneous injection. In the APCs, the encapsulated cell membrane and RNA from engineered cells, which have disturbed splicing resembling the metastatic cells, provide neoantigens of metastatic cancer in advance. Moreover, the sonosensitizer Ce6 together with ultrasound irradiation promotes mRNA escape from endosome, and augments antigen presentation. Through 4T1 syngeneic mouse model, it has been proved that the proposed nanovaccine is efficient to elicit antitumor immunity and thus prevent cancer metastasis.

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“…In turn, siRNA could be delivered to the cytoplasm effectively and used in combined ultrasound and gene therapy for tumors. [80] Hence, ultrasound-responsive nanocarriers have great potential for specific drug delivery to tumors. Notably, Jin et al demonstrated a kinetically activating nanoadjuvant (K-nanoadjuvant) that could dynamically integrate two waves of innate immune stimuli, resulting in effective antitumor immunity without immune cell exhaustion.…”

Section: Other Single-responsivementioning

confidence: 99%

Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

Liu,

Wen,

Huang

et al. 2023

Advanced Therapeutics

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Nanotechnology has been widely used in drug design in recent years, showing great potential and advantages in tumor therapy. However, the application of most traditional nanomedicines is still limited by low drug loading rate, poor targeting ability, and systemic toxicity. Based on the characteristics of tumor microenvironments, numerous studies indicate that the construction of stimuli‐responsive nanocarriers can effectively solve the above problems by improving delivery efficiency, reducing side effects, and enhancing targeting. A significant feature of responsive nanocarriers is that they can release and activate drugs at specific sites under stimulus, including internal stimuli (e.g., pH, reactive oxygen species (ROS), glutathione (GSH), enzyme, hypoxia, adenosine‐triphosphate (ATP), etc.) and external stimuli (e.g., light, thermo, ultrasound, etc.). Of note, learning about various pathways of responses can enable researchers to effectively design responsive nanocarriers for tumor therapy. Herein, this review focuses on the stimuli‐responsive strategies of nanocarriers for tumor therapy. In addition, the role of responsive nanocarriers in synergistic tumor therapy is also discussed. The expectation of this review is to provide ideas for the design of practical and effective responsive nanocarriers.

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A hybrid nanoassembly for ultrasound-inducible cytosolic siRNA delivery and cancer sono-gene therapy

Cited by 11 publications

References 36 publications

Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives

Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives

Ultrasound Responsive Nanovaccine Armed with Engineered Cancer Cell Membrane and RNA to Prevent Foreseeable Metastasis

Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

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