A hydrogen-bonded antibacterial curdlan-tannic acid hydrogel with an antioxidant and hemostatic function for wound healing

Zhou, Zongbao; Xiao, Jiangwei; Guan, Shuwen; Geng, Zhijie; Zhao, Ruifang; Gao, Botao

doi:10.1016/j.carbpol.2022.119235

Cited by 118 publications

(48 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further investigate the potential of the PDG hydrogel to be applied in biomedical fields, the cytocompatibility of the PDG hydrogel was evaluated by coculturing L929 fibroblasts with different concentrations of hydrogel extract . As shown in Figure a, after coincubation for 24 h, the CCK-8 assay showed that cell viability was higher than 100% when the concentration of the hydrogel extract was no more than 250 μg mL –1 , indicating that the PDG hydrogel was not cytotoxic . Moreover, abundant live cells with green fluorescence and virtually no dead cells with red fluorescence were seen in the images from the live/dead assays (Figure S6a).…”

Section: Resultsmentioning

confidence: 99%

Biomineralization-Inspired Intermediate Precursor for the Controllable Gelation of Polyphenol–Macromolecule Hydrogels

Tang

Wang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Hydrogels composed of polyphenols and various macromolecules have been widely reported to have the advantage of facile preparation, mainly through the formation of hydrogen bonds. However, the traditional preparation method involves the direct mixing of polyphenols and macromolecules, which generally occurs too quickly and uncontrollably, and results in poor homogeneity, injectability, and shape designability. Here, inspired by the intermediate precursor during biomineralization, to facilitate transformation in a controllable way, we propose a novel and universal internal gelation method that creates an intermediate precursor by controlling the pH value to manipulate the elimination and generation of hydrogen bonds between a polyphenol and macromolecules. The precursor strategy greatly improves the homogeneity, injectability, and shape designability of the hydrogel while also achieving a controllable gelation process, and the gelation time can be accurately adjusted. The hydrogels prepared with this method exhibited superior capability to seal leaks, provided complete wound coverage, and showed the potential to be a shape-designable wearable strain sensor. Our study opens up a new way to construct and apply polyphenol–macromolecule hydrogels in a more controllable manner.

show abstract

Section: Resultsmentioning

confidence: 99%

Biomineralization-Inspired Intermediate Precursor for the Controllable Gelation of Polyphenol–Macromolecule Hydrogels

Tang

Wang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Thus, drug delivery systems were designed by chemical [258] or physical [259,260] crosslinking curdlan derivatives. Hybrid networks of curdlan and tannic acid prepared by annealing technique showed antioxidant properties and hemostatic functions, being candidates for wound healing [261]. among the functional groups help the network to preserve its structural integrity without damage after submitted to successive low and high deformation cycles.…”

Section: Other Polyssacharidesmentioning

confidence: 99%

“…Thus, drug delivery systems were designed by chemical [258] or physical [259,260] crosslinking curdlan derivatives. Hybrid networks of curdlan and tannic acid prepared by annealing technique showed antioxidant properties and hemostatic functions, being candidates for wound healing [261]. Tragacanth gum is a multi-branched heterogeneous polysaccharide containing two fractions of tragacanthic acid and arabinogalactan with good biodegradability and biocompatibility, antioxidant activity, high structural stability against environmental agents, and low cost.…”

Section: Other Polyssacharidesmentioning

confidence: 99%

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

Bercea¹

2022

Polymers

View full text Add to dashboard Cite

Hydrogels, as interconnected networks (polymer mesh; physically, chemically, or dynamic crosslinked networks) incorporating a high amount of water, present structural characteristics similar to soft natural tissue. They enable the diffusion of different molecules (ions, drugs, and grow factors) and have the ability to take over the action of external factors. Their nature provides a wide variety of raw materials and inspiration for functional soft matter obtained by complex mechanisms and hierarchical self-assembly. Over the last decade, many studies focused on developing innovative and high-performance materials, with new or improved functions, by mimicking biological structures at different length scales. Hydrogels with natural or synthetic origin can be engineered as bulk materials, micro- or nanoparticles, patches, membranes, supramolecular pathways, bio-inks, etc. The specific features of hydrogels make them suitable for a wide variety of applications, including tissue engineering scaffolds (repair/regeneration), wound healing, drug delivery carriers, bio-inks, soft robotics, sensors, actuators, catalysis, food safety, and hygiene products. This review is focused on recent advances in the field of bioinspired hydrogels that can serve as platforms for life-science applications. A brief outlook on the actual trends and future directions is also presented.

show abstract

“…Here, we prepared versatile nIon 2+ -COS/SA physically crosslinked double-network hydrogel film (abbreviated as COS/SA/nM 2+ PDF) by the casting and in -situ spray method [12]. The physicochemical properties, antimicrobial properties, antioxidant properties, as well as cytocompatibility and ability to promote wound healing of COS/SA/nM 2+ PDF were also systematically characterized and evaluated in a series of experiments [13].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing

et al. 2022

View full text Add to dashboard Cite

The development of an efficient and convenient material to improve skin tissue regeneration is a major challenge in healthcare. Inspired by the theory of moist wound healing, portable chitooligosaccharide (COS)/sodium alginate (SA) dual-net gel films containing multiple metal ions were prepared by a casting and in -situ spray method, which can be used to significantly promote wound healing without the use of therapeutic drugs. A variety of divalent cations was introduced in this experiment to improve the advantages of each metal ion by forming metal ion chelates with COS. Moreover, the physicochemical properties and antioxidant properties of nIon2+-COS/SA gel films were systematically characterized and evaluated by in vitro experiments. The gel films showed good antibacterial activity against Gram-negative and Gram-positive bacteria. In addition, the gel films showed good cytocompatibility in cellular experiments, and the gel films with Zn2+ and Sr2+ addition significantly accelerated wound healing in whole skin defect model experiments. Therefore, this nIon2+-COS/SA gel film is an ideal candidate material for wound dressing.

show abstract

A hydrogen-bonded antibacterial curdlan-tannic acid hydrogel with an antioxidant and hemostatic function for wound healing

Cited by 118 publications

References 38 publications

Biomineralization-Inspired Intermediate Precursor for the Controllable Gelation of Polyphenol–Macromolecule Hydrogels

Biomineralization-Inspired Intermediate Precursor for the Controllable Gelation of Polyphenol–Macromolecule Hydrogels

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing

Contact Info

Product

Resources

About