A hydrostable anionic zinc-organic framework carrier with a bcu topology for drug delivery

Abstract

A hydrostable anionic zinc-organic open framework with a bcu topology was synthesized based on 2,5-furandicarboxylate ligand by a solvothermal process and exhibited a 17.2 wt% 5-fluorouracil payload, constituting a negligible cytotoxicity effect.

Retracted: A Porous Zn2(abct) Framework as an Efficient Carrier for 5‐Fu Delivery and Inhibiting Human Liver Cancer Cells

“…Region 2 reveals a slow and steady release over a long period of time, which can be attributed to the normal desorption, diffusion, and dissolution processes of the drug from pores to the medium. This is similar to results observed in other MOF‐based controlled drug delivery systems under different pH conditions . Additionally, the PXRD pattern of after drug release shows strong diffraction peaks that agree well with the original 1 , suggesting that compound 1 is stable under the simulated physiological conditions and can be used as an ideal drug carrier.…”

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

“…56 In addition, if the buffer solution that drug-loaded ZIF-8 comes into contact with during use contains inorganic anions that can form complexes with the central ion Zn 2+ of ZIF-8, its stability is also affected, which also limits its application as a drug sustained-release carrier. 57 Luzuriaga et al studied the stability of ZIF-8 single crystals in common laboratory buffers (phosphate buffer and bicarbonate buffer), cell culture media, serum, and whole cell culture media, which provides a reference for the choice of buffer for sustained release of drugs in vitro and in vivo. 58 The size of ZIF-8 particles will also affect the drug release process.…”

Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

“…Inorganic carriers have well-defined porosity, stability, high drug loading, and enable controlled drug release, but they are hard to degrade and be removed from body [ 24 ]. Based on the above research, metal–organic frameworks (MOFs) are being widely used as drug carriers due to their unique characteristics, for example, high porosity, large specific surface area, surface paintable, pore size tunable, structural stability, non-toxicity, and biocompatibility [ 25 , 26 , 27 , 28 ], The Materials of Institut Lavoisiser (MIL) series is a famous type of MOF, characterized by the extremely flexible skeleton of the material, and the material structure changes between having a big hole and a narrow hole when stimulated. MIL-53(Fe) is an iron (III) carboxylate MOF [ 29 , 30 ].…”