A Hydroxychalcone Derived from Cinnamon Functions as a Mimetic for Insulin in 3T3-L1 Adipocytes

Abstract

Together, these results demonstrate that the MHCP is an effective mimetic of insulin. MHCP may be useful in the treatment of insulin resistance and in the study of the pathways leading to glucose utilization in cells.

Hydro-Alcoholic Cinnamon Extract, Enhances Glucose Transporter Isotype-4 Translocation from Intracellular Compartments into the Cytoplasmic Membrane of C2C12 Myotubes

“…Previous studies have shown that 1-6 g/day cinnamon powder intake reduces blood glucose, total cholesterol and LDL-Cholesterol in human [16]. Also it is shown that methyl hydroxychalecon, a cinnamon derived component, mimics insulin effects on 3T3-L1 cell line and increases glycogen synthase kinase, glucose uptake and insulin receptor (IR) contents [1]. Other studies have shown GLUT4 enhancement under different concentrations of cinnamon extract or dihydrocinnamic acid (DHH105), a derivative of cinnamon, on GLUT4 content in animal adipose tissue [17] or 3T3-L1 cell line, a good model for studding fat tissue metabolism [14].…”

“…Diabetes is the most prevalent metabolic disease worldwide and the most cases are insulin resistant or type-2 diabetic patients [1]. Insulin resistance results to pathologic complications such as hyperinsulinemia, hyperglycemia and glucose toxicity, glucose intolerance, hypertriglyceridemia, high blood pressure, neuropathy, retinopathy, nephropathy, ketoacidosis and death [2][3][4].…”

The Effect of Cinnamon on A1C Among Adolescents With Type 1 Diabetes

“…Several in vitro investigations reported the insulinsensitizing effect of cinnamon (1)(2)(3)(4). Using a rat model, Qin et al (5) (2) observed that when cinnamon and insulin were combined in vitro, the effect was greater than was expected, implying a synergistic relationship. Additionally, Kim et al (6) proposed that cinnamon acts by increasing endogenous insulin production, rather than by a target-based mechanism.…”

“…Anderson et al (1) suggested that doubly linked, water-soluble A-type polymers, possibly misidentified earlier as methylhydroxychalcone polymers (2), are the active compounds. Several in vitro investigations reported the insulinsensitizing effect of cinnamon (1)(2)(3)(4).…”

“…Anderson et al (1) suggested that doubly linked, water-soluble A-type polymers, possibly misidentified earlier as methylhydroxychalcone polymers (2), are the active compounds. Several in vitro investigations reported the insulinsensitizing effect of cinnamon (1)(2)(3)(4). Using a rat model, Qin et al (5) (2) observed that when cinnamon and insulin were combined in vitro, the effect was greater than was expected, implying a synergistic relationship.…”