A hypertensive father, but not hypertensive mother, determines blood pressure in normotensive male offspring through body mass index

Abstract

This investigation was to assess the role of genetic loading of hypertensive parents in the determination of blood pressure (BP) in their normotensive offspring. The medical check-up data from 7279 Japanese university students aged 19.22 ± 0.01 years were analysed of which 641 students had only one hypertensive parent with or without hypertensive grandparents, and from this number 609 cases were available for the present analysis. The BP in the students having only one hypertensive parent were in the normotensive range, but was significantly higher than in those students without hypertensive relatives. Analyses of the data from the students having only one hypertensive parent revealed that systolic BP (SBP) and body mass index (BMI) were higher in the male than in the female students. In

Review of the Y chromosome and hypertension

“…We crossed SHR/crl with our WKY rats and failed to find an SHR Y chromosome blood pressure effect (9). Recent human studies further support our hypothesis and show that a hypertensive father but not a hypertensive mother affects blood pressure in normotensive male offspring through body mass index (10). Also, Lemne (11) showed that there was increased blood pressure reactivity in children of borderline hypertensive fathers.…”

Y-Chromosome Transfer Induces Changes in Blood Pressure and Blood Lipids in SHR

“…10 Finally, studies in the sons of hypertensive parents suggest a possible role of the human Y chromosome in the determination of BP and body mass index in men. 44 Thus, the relevance of our current findings in the SHR-BN rat model for human hypertension and associated metabolic disturbances could be tested in association studies that use polymorphisms in candidate genes on the Y chromosome to screen human populations.…”

The Y Chromosome Effect on Blood Pressure in Two European Populations

“…[3][4][5][6][7][8] Moreover, human studies have shown that a hypertensive father but not a mother affects BP in normotensive male offspring. 9 Recently, Ellis et al 10 reported an association between an increased risk of elevated diastolic blood pressure (DBP) and a biallelic polymorphism on the NRY region of the Y chromosome in 409 subjects recruited from the general population in Victoria, Australia. However, it cannot be excluded that other polymorphic loci contained within the NRY region of the Y chromosome or other autosomal loci might interact with the HindIII(ϩ/Ϫ) variant to affect systolic BP (SBP) and DBP.…”