A hypochlorite-activatable persistent luminescence nanoprobe for assisted tumor resection

Zhang, Zhouyu; Wei, Zi-Jin; Sun, Mengjie; Yan, Zichao; Yin, Chang; Wang, Wei; Yuan, Zhi

doi:10.1039/d3qm01308a

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…In contrast, the reconstructed PersL lifetime-based images showed consistent average lifetime values, which were significant less reliant on the penetration depth (Figure B). Notably, compared to the current PersL intensity-based imaging mode of hypochlorite, the PersL lifetime-based mode demonstrated more high-fidelity biosensing performance. − These results showed that the PersL lifetime-based nanoprobe exhibited distinguished reliability and anti-interference ability for further in vivo biosensing.…”

Section: Resultsmentioning

confidence: 92%

Persistent Luminescence Lifetime-Based Near-Infrared Nanoplatform via Deep Learning for High-Fidelity Biosensing of Hypochlorite

Feng,

Yang,

Rao

et al. 2024

Anal. Chem.

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In light of deep tissue penetration and ultralow background, near-infrared (NIR) persistent luminescence (PersL) bioprobes have become powerful tools for bioapplications. However, the inhomogeneous signal attenuation may significantly limit its application for precise biosensing owing to tissue absorption and scattering. In this work, a PersL lifetime-based nanoplatform via deep learning was proposed for high-fidelity bioimaging and biosensing in vivo. The persistent luminescence imaging network (PLI-Net), which consisted of a 3D-deep convolutional neural network (3D-CNN) and the PersL imaging system, was logically constructed to accurately extract the lifetime feature from the profile of PersL intensity-based decay images. Significantly, the NIR PersL nanomaterials represented by Zn 1+x Ga 2−2x Sn x O 4 : 0.4 % Cr (ZGSO) were precisely adjusted over their lifetime, enabling the PersL lifetime-based imaging with high-contrast signals. Inspired by the adjustable and reliable PersL lifetime imaging of ZGSO NPs, a proof-of-concept PersL nanoplatform was further developed and showed exceptional analytical performance for hypochlorite detection via a luminescence resonance energy transfer process. Remarkably, on the merits of the dependable and anti-interference PersL lifetimes, this PersL lifetime-based nanoprobe provided highly sensitive and accurate imaging of both endogenous and exogenous hypochlorite. This breakthrough opened up a new way for the development of high-fidelity biosensing in complex matrix systems.

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Section: Resultsmentioning

confidence: 92%

Persistent Luminescence Lifetime-Based Near-Infrared Nanoplatform via Deep Learning for High-Fidelity Biosensing of Hypochlorite

Feng,

Yang,

Rao

et al. 2024

Anal. Chem.

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“…In contrast to other optical NPs, NIR PLNPs can produce NIR PersL for a long time after being excited, which can completely eliminate the interference of background fluorescence with imaging quality and greatly improve the imaging sensitivity. 18–24…”

Section: Introductionmentioning

confidence: 99%

X-ray activated near-infrared persistent luminescence nanoparticles for trimodality in vivo imaging

Wang,

Sun,

et al. 2024

Biomater. Sci.

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Photosensitizer-Free Nanophosphor-Based theranostic probe for controllable photodynamic and photothermal visualization therapy

Sun,

Zhang,

Yin

et al. 2024

Chemical Engineering Journal

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A hypochlorite-activatable persistent luminescence nanoprobe for assisted tumor resection

Abstract: Surgical resection is widely recognized as one of the most effective treatments for cancer. However, it requires precise and convenient visualization of tumor boundaries to assist surgeons. Persistent luminescence nanoparticles...

Cited by 4 publications

References 39 publications

Persistent Luminescence Lifetime-Based Near-Infrared Nanoplatform via Deep Learning for High-Fidelity Biosensing of Hypochlorite

Persistent Luminescence Lifetime-Based Near-Infrared Nanoplatform via Deep Learning for High-Fidelity Biosensing of Hypochlorite

X-ray activated near-infrared persistent luminescence nanoparticles for trimodality in vivo imaging

Photosensitizer-Free Nanophosphor-Based theranostic probe for controllable photodynamic and photothermal visualization therapy

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