A hypothalamic pathway that suppresses aggression toward superior opponents

Wei, Dongyu; Osakada, Takuya; Guo, Zhichao; Yamaguchi, Takashi; Varshneya, Avni; Yan, Rongzhen; Jiang, Yiwen; Lin, Dayu

doi:10.1038/s41593-023-01297-5

Cited by 24 publications

(16 citation statements)

References 54 publications

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“…These differences in cyp19a1 expression are particularly interesting since the VMH is involved in the production of aggressive behavior across different species. Given the conserved functions of both aromatase and the VMH in controlling aggression, 18,40–45 we speculate that ARα governs aggressive displays in male A. burtoni through the enhancement of cyp19a1 expression in the ATn, which leads to enhanced synthesis and actions of estrogens within this region 7,10 . Importantly, cyp19a1 expression levels did not differ between ar1 mutants with one or two nonfunctional alleles, suggesting that there are not dosage‐related functions of the impacts of ar1 on cyp19a1 expression in the ATn, which mirror the findings on the behavioral deficits in these ar1 mutants 27 .…”

Section: Discussionmentioning

confidence: 95%

“…Extensive research suggests that VMH is critical for the production of aggressive and reproductive behaviors 44 , 45 , 55 , 56 . In zebrafish and A. burtoni , it has been shown that ARs modulate aggression 27,57 .…”

Section: Discussionmentioning

confidence: 99%

“…Yet, available findings have not tested the role of AR signaling in the VMH in the control of male‐typical aggression or aromatase expression in teleost or nonteleost vertebrate species. Instead, extensive evidence indicates that estrogenic signaling within the VMH is critical for the production of aggression in both male and female mice 44 , 45 . Dugger et al 58 .…”

Section: Discussionmentioning

confidence: 99%

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Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids

Lopez,

Alward

2024

Annals of the New York Academy of Sciences

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Social behaviors are regulated by sex steroid hormones, such as androgens and estrogens. However, the specific molecular and neural processes modulated by steroid hormones to generate social behaviors remain to be elucidated. We investigated whether some actions of androgen signaling in the control of social behavior may occur through the regulation of estradiol synthesis in the highly social cichlid fish, Astatotilapia burtoni. Specifically, we examined the expression of cyp19a1, a brain‐specific aromatase, in the brains of male A. burtoni lacking a functional ARα gene (ar1), which was recently found to be necessary for aggression in this species. We found that cyp19a1 expression is higher in wild‐type males compared to ar1 mutant males in the anterior tuberal nucleus (ATn), the putative fish homolog of the mammalian ventromedial hypothalamus, a brain region that is critical for aggression across taxa. Using in situ hybridization chain reaction, we determined that cyp19a1+ cells coexpress ar1 throughout the brain, including in the ATn. We speculate that ARα may modulate cyp19a1 expression in the ATn to govern aggression in A. burtoni. These studies provide novel insights into the hormonal mechanisms of social behavior in teleosts and lay a foundation for future functional studies.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids

Lopez,

Alward

2024

Annals of the New York Academy of Sciences

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“…The underlying neural mechanisms, while extensively studied in flies (3, 4), have generally remained elusive in vertebrates. Recent studies in mice, however, have yielded important findings: neurons expressing the estrogen receptor (ESR) subtype ESR1 in the medial preoptic area (MPOA) and the ventrolateral part of the ventromedial hypothalamus (VMHvl), which evoke mating and aggression, respectively, inhibit each other to ensure mutually exclusive displays of these behaviors (5, 6).…”

Section: Introductionmentioning

confidence: 99%

The decision of male medaka to mate or fight depends on two complementary androgen signaling pathways

Nishiike,

Okubo

2024

Preprint

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Adult male animals typically court and attempt to mate with females, while attacking other males. Emerging evidence from mice indicates that neurons expressing the estrogen receptor ESR1 in behaviorally relevant brain regions play a central role in mediating these mutually exclusive behavioral responses to conspecifics. However, the findings in mice are unlikely to apply to most other vertebrates, where androgens, rather than estrogens, have been implicated in male behaviors. Here we report that male medaka (Oryzias latipes) lacking one of the two androgen receptor subtypes (Ara) are less aggressive toward other males and instead actively court them, while those lacking the other subtype (Arb) are less motivated to mate with females and conversely attack them. These findings indicate that, in male medaka, the Ara- and Arb-mediated androgen signaling pathways facilitate appropriate behavioral responses, while simultaneously suppressing inappropriate responses, to males and females, respectively. Notably, males lacking either receptor retain the ability to discriminate the sex of conspecifics, suggesting a defect in the subsequent decision-making process to mate or fight. We further show that Ara and Arb are expressed in intermingled but largely distinct populations of neurons, and stimulate the expression of different behaviorally relevant genes including galanin and vasotocin, respectively. Collectively, our results demonstrate that male teleosts make adaptive decisions to mate or fight as a result of the activation of one of two complementary androgen signaling pathways, depending on the sex of the conspecific that they encounter.

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“…The imitation of selective release of excitatory–inhibitory neurotransmitters in an individual synaptic transistor can enable a reconfigurable hardware platform, which is crucial for adaptive computing. − However, achieving the concomitant excitatory and inhibitory plasticity with a single organic field-effect transistor (OFET) remains a challenge since most semiconductor materials are unipolar, with an imbalance in hole and electron carrier concentrations . Using light irradiation as an additional terminal allows the introduction of photogenerated electrons in p -type synaptic OFETs but leads to integration complexity. , To address this issue, unipolar spike voltage-dependent plasticity (USVDP) is proposed. − The modulation of conductance in USVDP is regulated by voltage amplitude, as opposed to the frequency-dependent regulation observed in spike-timing-dependent plasticity (STDP).…”

Section: Introductionmentioning

confidence: 99%

Achieving Reconfigurable Excitatory–Inhibitory Response in Unipolar Synaptic Memtransistors by the Synergistic Effects of Electric Double Layer and Charge Trapping

Zheng,

Wang,

et al. 2024

ACS Appl. Electron. Mater.

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Mimicking the concomitant and independently expressed excitatory−inhibitory response in one unipolar synaptic transistor is desirable but remains a significant challenge. Here, this study employs a dual-mechanism approach in designing a memtransistor to achieve unipolar spike voltagedependent plasticity (USVDP). The transition of synaptic excitation and inhibition depends on the amplitude rather than the polarity of the applied voltage, arising from the dynamic competition between the electric double-layer (EDL) and charge-trapping effects. The reconfigurable characteristic of the memtransistor remains stable for 1000 consecutive hysteresis loops. Our research highlights the coupling of EDL and charge-trapping effects for reconfigurable neuromorphic systems.

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A hypothalamic pathway that suppresses aggression toward superior opponents

Cited by 24 publications

References 54 publications

Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids

Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids

The decision of male medaka to mate or fight depends on two complementary androgen signaling pathways

Achieving Reconfigurable Excitatory–Inhibitory Response in Unipolar Synaptic Memtransistors by the Synergistic Effects of Electric Double Layer and Charge Trapping

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