A hypothesis for the function of collagen X

Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels

“…Surprisingly, mice homozygous for an inactive allele (knockout) were initially judged to have no phenotype (Rosati et al, 1994). Subsequently, however, such mice were found to have a reduced height of the resting zone in epiphyseal cartilage, atypical distribution of granular matrix material, and matrix vesicles in the resting and proliferative zone (Cheah et al, 1996). In addition, the structure of trabecular bone was abnormal.…”