Supply chain resilience (SCRE) has emerged as a critical capability for mitigating the challenges posed by supply chain risks and vulnerabilities. To address the question of how businesses can enhance SCRE via the integration of organizational, technological, and environmental factors, this paper aims to develop a hierarchical model based on the Technology-Organization-Environment (TOE) framework. The model utilizes Interpretive Structural Modeling (ISM) to analyze the hierarchical relationships among these enablers. By assessing the driving power and dependence power of these enablers, a classification is derived using the Matrix of Cross Impact Multiplications Applied to Classification (MICMAC)method. This study focuses on five selected enablers and presents a streamlined model along with six propositions to validate their impact on SCRE. The findings of this developed model offer valuable insights into the critical strategies that practitioners can employ to enhance SCRE, ensuring uninterrupted operations even in dynamic and complex environments. This research contributes to the growing body of knowledge on SCRE, providing a structured framework for organizations to navigate the challenges of an ever-changing business landscape.