A In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kB

Tukhvatulin, Amir I.; Logunov, Denis Y.; Gitlin, Ilya; Шмаров, М. М.; Кудан, П. В.; Аджиева, А. А.; Moroz, A F; Kostyukova, N. N.; Burdelya, Lyudmila; Naroditsky, Boris S.; Гинцбург, А Л; Gudkov, Andrei V.

doi:10.32607/20758251-2011-3-1-77-84

Cited by 13 publications

(8 citation statements)

References 11 publications

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“…Conversely, the role of NLRs in the regulation of inflammation and angiogenesis is not yet fully understood. Some members of the NLR family, including NOD1 and NOD2 were reported to activate NF-κB [168,169], while other members, including NLRP2 [170], NLRP6 [171,172], NLRP12 [173,174], NLRC3 [173] and NLRX1 [175] were reported to negatively regulate NF-κB signaling. However, the inhibitory functions of these NLRs are not well understood [176].…”

Section: Nlrs In Diabetic Retinopathymentioning

confidence: 99%

NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy

Lim

Wieser

Ganga

et al. 2020

IJMS

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Diabetic retinopathy (DR) is an ocular complication of diabetes mellitus (DM). International Diabetic Federations (IDF) estimates up to 629 million people with DM by the year 2045 worldwide. Nearly 50% of DM patients will show evidence of diabetic-related eye problems. Therapeutic interventions for DR are limited and mostly involve surgical intervention at the late-stages of the disease. The lack of early-stage diagnostic tools and therapies, especially in DR, demands a better understanding of the biological processes involved in the etiology of disease progression. The recent surge in literature associated with NOD-like receptors (NLRs) has gained massive attraction due to their involvement in mediating the innate immune response and perpetuating inflammatory pathways, a central phenomenon found in the pathogenesis of ocular diseases including DR. The NLR family of receptors are expressed in different eye tissues during pathological conditions suggesting their potential roles in dry eye, ocular infection, retinal ischemia, cataract, glaucoma, age-related macular degeneration (AMD), diabetic macular edema (DME) and DR. Our group is interested in studying the critical early components involved in the immune cell infiltration and inflammatory pathways involved in the progression of DR. Recently, we reported that NLRP3 inflammasome might play a pivotal role in the pathogenesis of DR. This comprehensive review summarizes the findings of NLRs expression in the ocular tissues with special emphasis on its presence in the retinal microglia and DR pathogenesis.

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Section: Nlrs In Diabetic Retinopathymentioning

confidence: 99%

NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy

Lim

Wieser

Ganga

et al. 2020

IJMS

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“…Diaminopimelic acid is also the active constituent of other environmental PAMPs. For example, dipeptide γ‐D‐glutamyl‐meso‐diaminopimelic acid (iE‐DAP, MW: 319·3), L‐alanyl‐γ‐D‐glutamyl‐meso‐diaminopimelic acid (MW: 390·39) and lauroyl‐γ‐D‐glutamyl‐meso‐diaminopimelic acid (MW: 501·61) are components of peptidoglycan in the cell walls of Gram‐negative and certain groups of Gram‐positive bacteria .…”

Section: Kd Aetiologymentioning

confidence: 99%

Kawasaki disease: a matter of innate immunity

Hara

Nakashima

Sakai

et al. 2016

Clinical and Experimental Immunology

120

125

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SummaryKawasaki disease (KD) is an acute systemic vasculitis of childhood that does not have a known cause or aetiology. The epidemiological features (existence of epidemics, community outbreaks and seasonality), unique age distribution and clinical symptoms and signs of KD suggest that the disease is caused by one or more infectious environmental triggers. However, KD is not transmitted person-to-person and does not occur in clusters within households, schools or nurseries. KD is a self-limited illness that is not associated with the production of autoantibodies or the deposition of immune complexes, and it rarely recurs. Regarding the underlying pathophysiology of KD, innate immune activity (the inflammasome) is believed to play a role in the development of KD vasculitis, based on the results of studies with animal models and the clinical and laboratory findings of KD patients. Animal studies have demonstrated that innate immune pathogen-associated molecular patterns (PAMPs) can cause vasculitis independently of acquired immunity and have provided valuable insights regarding the underlying mechanisms of this phenomenon. To validate this concept, we recently searched for KD-specific PAMPs and identified such molecules with high specificity and sensitivity. These molecules have structures similar to those of microbe-associated molecular patterns (MAMPs), as shown by liquid chromatography-tandem mass spectrometry. We propose herein that KD is an innate immune disorder resulting from the exposure of a genetically predisposed individual to microbe-derived innate immune stimulants and that it is not a typical infectious disease.

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“… 12 NOD1 is highly expressed in inflammatory cells, which can active multiple inflammation associated with signaling pathways and result in inflammatory cytokine secretion. 19 , 20 In this study, we investigated the regulatory role of NOD1 in COPD, and found that the expression level of NOD1 was significantly increased in the lung tissues of COPD mice. Similar to COPD treatment, NOD1 activation could facilitate inflammatory responses and increase the number of macrophages, neutrophils and lymphocytes in BALF of mice.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18] NOD1 is highly expressed in inflammatory cells, which activates the NF-κB signaling and results in the secretion of inflammatory cytokines. [19][20][21] Recent studies have reported that NOD1 activation could cause tissue inflammation in the heart and aggravate cardiac ischemia-reperfusion injury. 16,22 NOD1 is widely expressed in lung tissues.…”

Section: Introductionmentioning

confidence: 99%

Nucleotide-Oligomerizing Domain-1 Activation Exaggerates Cigarette Smoke-Induced Chronic Obstructive Pulmonary-Like Disease in Mice

Han¹,

Li²,

Du³

et al. 2021

COPD

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Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive condition related to abnormal inflammatory responses. As an inflammatory driver, nucleotide-binding oligomerizing domain-1 (NOD1) is highly expressed in pulmonary inflammatory cells; however, the roles of NOD1 in COPD are unknown. Methods: A COPD mouse model was established by lipopolysaccharides tracheal instillation plus cigarette smoke (CS) exposure. NOD1 activation was induced by C12-iE-DAP (iE) treatment in both control and COPD mice. Inflammatory infiltration, pulmonary histological damage and gene expression were measured to evaluate the lung function of treated mice. Results: The results showed that NOD1 was up-regulated in COPD mice, which significantly exaggerated CS-induced impairment of lung function, demonstrated by increased airway resistance, functional residual capacity and pulmonary damages. Mechanistically, NOD1 activation strongly activated the TLR4/NF-κB signaling pathway and then increased inflammatory responses and promoted the secretion of inflammatory cytokines. Discussion: This study demonstrates that NOD1 is an important risk factor in the progression of COPD; therefore, targeting NOD1 in lung tissues is a potential strategy for COPD treatment.

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A In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kB

Cited by 13 publications

References 11 publications

NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy

NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy

Kawasaki disease: a matter of innate immunity

Nucleotide-Oligomerizing Domain-1 Activation Exaggerates Cigarette Smoke-Induced Chronic Obstructive Pulmonary-Like Disease in Mice

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