A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese

Abstract

Visceral adipose dysfunction is a major cause of metabolic disorders. However, there is lack of a clinical index for prediction of visceral fat dysfunction in Asians. The present study aims to establish a visceral adiposity index for evaluation of metabolic health status in Chinese, the largest Asian ethnic group. 485 subjects were recruited from Lianqian Community, Xiamen and received abdominal computed tomography(CT) for visceral fat area. A Chinese visceral adiposity index (CVAI) was created using multivariate linear regression analyses, and was further validated in 6495 subjects recruited from Changfeng Community, Shanghai. CVAI was well associated with visceral obesity (r = 0.68, P < 0.001) and HOMA-IR (r = 0.60, P < 0.001). The AUROCs were 0.89(0.88–0.90), 0.72(0.71–0.73), 0.69(0.68–0.71) and 0.67(0.65–0.68) for determination of metabolic syndrome, hypertension, diabetes and prediabetes, respectively. CVAI was more valuable compared to BMI and waist circumference in evaluation of metabolic risks (all P < 0.001), even in subjects with metabolically unhealthy normal weight (MUNW) and metabolically healthy obese/overweight (MHO). This study demonstrates that CVAI is a reliable and applicable index for evaluation of visceral fat dysfunction in Chinese. It might be used to evaluate metabolic health status in Asians.

Association of visceral adiposity and its longitudinal increase with the risk of diabetes in Chinese adults: A prospective cohort study

“…A CVAI was recently established to estimate the visceral adipose area . The current prospective study further showed that CVAI could be used as a simple clinical index for visceral adiposity to predict the risks of prediabetes and diabetes irrespective of age, gender, obesity, metabolic syndrome, or its components.…”

“…Our results indicated that visceral fat area estimated by CVAI had a better prediction value than other traditional estimates of obesity for the prediction of incident prediabetes and diabetes. Importantly, the CVAI is mainly composed of the components of metabolic syndrome (BMI, waist circumference, serum TG, and HDL‐c), which are easily available in clinical practice . Age was also included as a covariate in CVAI.…”

“…Based on the prediction equation for visceral adiposity in Chinese populations, the visceral adiposity area was estimated by CVAI as follows: Chinese visceral adiposity index was strongly and positively associated with visceral fat area ( r = 0.68, p < 0.0001), and the AUROC of CVAI for visceral obesity was 0.83 (0.79‐0.86) according to our previous study …”

Comparison of adiposity indices in relation to prehypertension by age and gender: A community‐based survey in Henan, China

“…PBF was calculated as the total mass of fat divided by total body mass. VFI is a novel and accurate and reliable indicator for assessing body fat stored around important internal organs, which is significantly associated with many health‐related outcomes, such as prehypertension, adipose tissue dysfunction, and type 2 diabetes . Bioimpedance analysis is a measurement technique based on electrophysiological characteristics of the dielectric and conductive properties of human tissues .…”

Improved skeletal muscle energy metabolism relates to the recovery of β cell function by intensive insulin therapy in drug naïve type 2 diabetes

“…Dual‐energy X‐ray absorptiometry scanning (Lunar iDXA, GE, USA) was applied for assessing lean body mass and fat mass in all subjects. Besides, Chinese visceral adiposity index (CVAI), a reliable index for evaluation of visceral adiposity area in Chinese, was calculated as follows: For males: CVAI = −267.93 + 0.68 × age (years) + 0.03 × BMI (kg/m 2 ) + 4.00 × waist circumference (cm) + 22.00 × Log10TG (mmol/L) − 16.32 × HDL‐C (mmol/L). For females: CVAI = −187.32 + 1.71 × age (years) + 4.23 × BMI (kg/m 2 ) + 1.12 × waist circumference (cm) + 39.76 × Log10TG (mmol/L) − 11.66 × HDL‐C (mmol/L). …”