ObjectiveEvaluate the color and translucency of a nanoceramic resin subjected to hygiene practices and immersion in coffee over time.Materials and MethodsSpecimens (n = 80, HT and LT, 0.5‐mm thick) of a nanoceramic resin were obtained and were divided in groups according to the simulated oral hygiene: no intervention (NT), brushing with an electric brush and water (BN), brushing with an electric brush and toothpaste for 10 s (BT), and immersion in mouthwash for 30 s (MW). Oral hygiene practices were repeated after staining in coffee solution for 15, 48, 336, 1440, 8640, and 35,040 min. Spectral wavelengths were recorded with a spectrophotometer at each time. ∆E00, ∆L′, ∆C′, ∆H′, and TP00 were calculated by CIEDE2000 and were evaluated by 2‐way ANOVA, repeated measures ANOVA, and Tukey's HSD test (α = 0.05).ResultsANOVA showed significance among factors for ΔE00 (p < 0.05), with higher ΔE00 for NT‐HT (11.7) and NT‐LT (11.2). After T6 (2‐year simulation), the lowest values were found for BT‐HT (5.3) and BT‐LT (4.9). All groups showed a reduction in lightness and translucency and increased chroma and hue. However, the smallest variations were found in the BT groups (p < 0.05).ConclusionsBrushing with toothpaste effectively minimized the color change of NCRs caused by coffee staining.Clinical SignificanceOral hygiene practices, such as brushing with toothpaste, might be important to minimize staining of nanoceramic resin restorations, especially in patients who frequently consume coffee.