A Innovative Prognostic Symbol Based on Autophagy-Related Long Noncoding RNAs Signature Predicts in Low-Grade Glioma

Abstract

Autophagy is a highly conserved lysosomal degradation process essential in tumorigenesis. However, the involvement of autophagy-related lncRNA in low-grade gliomas (LGG) remains a pending question. Efforts were made to establish an autophagy-related lncRNA signature prognostic in LGG patients, and to explore the behind potential function. We used Univariate Cox, Least Absolute Shrinkage and Selection Operator (Lasso), and Multivariate Cox regression models were designed to establish an autophagy-related lncRNA prognostic signature. Kaplan-Meier survival analysis, receiver operating characteristic (ROC) curve, nomogram, C-index, calibration curve and clinical decision-making curve were adopted to assess the predictive capability of the identified signature.A signature comprising 9 autophagy-related lncRNAs (AL136964.1, ARHGEF26-AS1, PCED1B-AS1, AS104072.1, PRKCQ-AS1, LINC00957, AS125616.1, PSMB8-AS1, and AC087741.1) was identified as a prognostic model. LGG patients were allocated into high- and low-risk cohorts depending on the median model-based Riskscore. The survival analysis showed a 10-year survival rate of 9.3% (95% CI: 1.91-45.3%) in high-risk LGG patients and 48.4% (95% CI: 24.7-95.0%) in low-risk individuals in the training set. While those of patients in the validation set were 13.48% (95% CI: 4.52-40.2%) for high-risk LGG patients and 48.4% (95% CI: 28.04-83.4%) for low-risk LGG patients, respectively. This suggested a relatively low survival in high-risk cases compared to low-risk individuals. In addition, LncRNA signature was independently prognostic and potentially associated with the progression of LGG. Taken together, our constructed 9 autophagy-related lncRNA signature may play a crucial part in the diagnosis and treatment for LGG, which may guide to open up a new avenues for tumor targeted therapy.

M7G-related LncRNAs: A comprehensive analysis of the prognosis and immunity in glioma

“…Many studies have shown the critical role of m 7 G in cancer development, mainly focusing on the regulation of tumor cell genesis and progression, but few investigations on cancer prognosis (Orellana et al, 2021;Rong et al, 2021;Xia et al, 2021). Several studies have recently emerged by constructing mRNA and lncRNA predictive signatures associated with glioma autophagy, pyrogenesis, m 6 A, and ferrogenesis can be used to predict the prognosis of glioma patients (Maimaiti et al, 2022) (Zhou et al, 2021a (Guan et al, 2021) (Shi et al, 2022). However, the study of prognostic m7Grelated lncRNAs in glioma has not been reported.…”

“…SNAI3-AS1, an m 7 G prognosis-associated lncRNA, is an important tumor modifier in hepatocellular carcinoma tumor progression (Li et al, 2020). Recently, it has been reported that autophagy-related lncRNA features can accurately predict the prognosis of glioma patients (Maimaiti et al, 2022). Ferroptosisassociated lncRNAs can also predict the prognosis of glioma patients (Shi et al, 2022).…”