A Japanese Case of Tinea Corporis Caused by <i>Arthroderma benhamiae</i>

Mochizuki, Takashi; Watanabe, Seiji; Kawasaki, Masanori; Tanabe, Hiroshi; Ishizaki, Hiroshi

doi:10.1111/j.1346-8138.2002.tb00253.x

Cited by 27 publications

(14 citation statements)

References 8 publications

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“…In contrast, infections caused by M. canis and zoophilic T. mentagrophytes are usually transmitted from pet animals with soft fur, and so the lesions tend to appear where the pet owner's skin is soft, i.e. the neck and face 14 . The lesions caused by T .…”

Section: Discussionmentioning

confidence: 99%

The first isolation in Japan of Trichophyton mentagrophytes var. erinacei causing tinea manuum

et al. 2004

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International Journal of Dermatology 2005, 44 , 765-768 765A 26-year-old woman with no family history of dermatophytosis presented with pruritic erythema on the right palm ( Fig. 1) in November 2002, 1 month after first noticing it. She had no lesions on the soles, toe webs, left palm, or nails. The erythema had been treated with topical steroids for 4 weeks, but had continued to expand. The erythema measured 42 mm × 36 mm, and was hyperemic and infiltrated unevenly. Its center showed no signs of healing, its periphery exhibited small vesicles, and its margin showed scales. On the scales, fungal hyphae and chains of arthroconidia were revealed by direct KOH test. The erythema was diagnosed as tinea manuum and was treated with topical terbinafine once daily. After several days of treatment, the erythema flared up and red papuloerythemas appeared on the back of both hands and on both forearms.Ten days after the first visit, the patient returned to our clinic for the treatment of newly developed eruptions. A trichophytin skin test produced an infiltrated erythema measuring 21 mm × 18 mm, confirming that the newly developed eruptions and exacerbated erythema on the right palm were due to a trichophytid reaction. Topical terbinafine was continued for the palm and fluocinolone acetonide ointment was applied on the newly developed eruptions on the arms from day 10 after the first visit. All the inflammatory eruptions subsided after 4 weeks of treatment and direct KOH test results were negative.The suspected cause of tinea manuum was the patient's pet female four-toed hedgehog ( Atelerix albiventris ) which she had kept for 4 years (Fig. 2). When she bought it from a local pet shop, it had desquamation on its body, but no lesions with loss of hair or quill and no dermatitis.The scaling decreased gradually with treatment given by a veterinarian.Three isolates of dermatophytes were obtained from the scale on the woman's palm (KMU 4455), scale removed from the hedgehog (KMU 4459-1), and a fallen-out quill (KMU 4459-2).KMU 4455 grew rapidly with an ivory-white and lightly powdery surface, and with concentric ripples at the periphery. The center of the colonies was fluffy and elevated slightly, with a yellow pigment beneath (Fig. 3). The strains from the hedgehog were morphologically similar to each other, and their colonies grew more slowly and had a more powdery texture than those of KMU 4455. KMU 4459-1 and KMU 4459-2 gave a positive urease test result, whereas KMU 4455 gave negative results even at day 7 of incubation. The microscopic findings of the three isolates were almost the same (Fig. 4). Numerous teardrop-shaped microconidia were produced along the sides of the rectangle of mycelium. Spherical microconidia clustered in some parts and some club-shaped, 2 -6-roomed macroconidia were observed. There were some poorly developed macroconidia and some elongated microconidia which were so large that they were intermediate in size between normal microconidia and macroconidia. There was no spiral body.The isolates were mate...

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Section: Discussionmentioning

confidence: 99%

The first isolation in Japan of Trichophyton mentagrophytes var. erinacei causing tinea manuum

et al. 2004

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“…We collected 23 Japanese strains of A. benhamiae, including the first isolates (5,6) from 1996, some of which had been documented in the literature (19)(20)(21)(22)(23)(24)(25)(26). These strains were speculated to have been imported from abroad after the survey in 1980 (4).…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of a Major Subgroup of Arthroderma benhamiae Isolated in Japan by Restriction Fragment Length Polymorphism Analysis of the Non-Transcribed Spacer Region of Ribosomal RNA Gene

et al. 2012

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SUMMARY: Arthroderma benhamiae vectored by small animals, such as household pets, causes tinea lesions on human skin. The number of tinea cases caused by this species is increasing in Japan. We attempted to develop a simple molecular method for strain discrimination, which is expected to be useful in molecular epidemiology. Out of the 61 strains of A. benhamiae registered at our institute, 46 A. benhamiae strains showed very high degrees of sequence similarity on cluster analysis of the internal transcribed spacer regions of ribosomal RNA (rRNA) genes. These 46 strains, including 22 strains isolated from Japan, were further used for strain typing by analyzing the non-transcribed spacer (NTS) region of the rRNA gene. Polymerase chain reaction was performed using a primer pair designed for amplification of a part of the NTS region, and the amplicons were successfully discriminated by restriction fragment length polymorphism (RFLP) analysis performed using MvaI. RFLP analysis showed 11 NTS types (NTS1-NTS11) among the 46 strains. Out of the 22 Japanese strains, 10 were of the NTS8 type; 6, of the NTS1 type; 3, of the NTS2 type; and 3, of the NTS5 type. Molecular typing showed consistency of NTS types among the strains isolated from different lesions on the same patient, among the strains derived from the same family, and among the strains from pets and their owners. We observed that 3 out of the 4 NTS types among the Japanese strains were detected outside Japan as well.

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“…A. benhamiae , a pathogen mainly carried by small pet animals, was first isolated in 1996 in Japan, with Southern blot hybridization identifying molecular polymorphisms in Japanese isolates . This method was able to identify a patient with a laboratory‐based A. benhamiae infection . Sequence analysis was then used to generate NTS specific primers and identify an RFLP site, enabling molecular typing (Fig.…”

Section: Intraspecies Subtyping and Strain Differentiation In Practicementioning

confidence: 99%

“…24 This method was able to identify a patient with a laboratory-based A. benhamiae infection. 25 Sequence analysis was then used to generate NTS specific primers and identify an RFLP site, enabling molecular typing (Fig. 1).…”

Section: Non-transcribed Spacer Regions Of Rdnamentioning

confidence: 99%

Molecular markers useful for epidemiology of dermatophytoses

Mochizuki

Takeda

Anzawa

2015

The Journal of Dermatology

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Dermatophytosis is a very common skin disorder and the most prevalent infectious disease treated by dermatologists. Recent developments in molecular techniques have markedly changed methods of identifying dermatophytes, with these methods showing intraspecies polymorphisms in some molecular markers. Intraspecies subtyping and strain differentiation have made possible the tracking of infections, the identification of common sources of infections and recurrence or reinfection after treatment. This review describes methods of intraspecies differentiation using mitochondrial DNA, random amplification of polymorphic DNA, non-transcribed spacer regions of ribosomal RNA genes and microsatellite markers, as well as their usefulness and limitations.

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A Japanese Case of Tinea Corporis Caused by Arthroderma benhamiae

Cited by 27 publications

References 8 publications

The first isolation in Japan of Trichophyton mentagrophytes var. erinacei causing tinea manuum

The first isolation in Japan of Trichophyton mentagrophytes var. erinacei causing tinea manuum

Molecular Epidemiology of a Major Subgroup of Arthroderma benhamiae Isolated in Japan by Restriction Fragment Length Polymorphism Analysis of the Non-Transcribed Spacer Region of Ribosomal RNA Gene

Molecular markers useful for epidemiology of dermatophytoses

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