A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

Abstract

Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer and chronic diseases promote the growth of nanomedicine. However, there are very few analytical and descriptive studies regarding the trajectory of nanomedicine, key research powers, present research landscape, focal investigative points, and future outlooks. Herein, articles and reviews published in the Science Citation Index Expanded of Web of Science Core Collection from first January 2000 to 18th July 2023 are analyzed. Herein, a bibliometric visualization of publication trends, countries/regions, institutions, journals, research categories, themes, references, and keywords is produced and elaborated. Nanomedicine‐related academic output is increasing since the COVID‐19 pandemic, solidifying the uneven global distribution of research performance. While China leads in terms of publication quantity and has numerous highly productive institutions, the USA has advantages in academic impact, commercialization, and industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, in which drug delivery and nanoparticles remain focal points. Current research focuses on integrating nanomedicine and cell ferroptosis induction in cancer immunotherapy. The keyword “burst testing” identifies promising research directions, including immunogenic cell death, chemodynamic therapy, tumor microenvironment, immunotherapy, and extracellular vesicles. The prospects, major challenges, and barriers to addressing these directions are discussed.

Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study

“…It also has certain limitations when it comes to literature retrieval. That being said, it is crucial to stress that the WoSCC database is generally accepted as the most extensively used database for bibliometric research (74)(75)(76).…”

Research trends in lipid-lowering therapies for coronary heart disease combined with hyperlipidemia: a bibliometric study and visual analysis

“…The inclusion criteria were as follows: 1) publications on lipid-lowering therapy for treating CHD with hyperlipidemia, including studies of patients with CHD combined with hyperlipidemia and animal models of CHD with hyperlipidemia (hyperlipidemia included simple hypercholesterolemia and hypertriglyceridemia), that assessed the correlation between lipidlowering therapies and disease; 2) studies published from 1 January 1986, to 31 December 2023, to ensure the inclusion of publications from 2023; 3) publications from the Web of Science (Core Collection) Citation Index Expanded (SCI-E) and Social Science Citation Index (SSCI) databases; 4) studies published as articles; and 5) studies published in the English language. The exclusion criteria were as follows: 1) reviews, meta-analyses, conference abstracts, letters, early access papers, conference proceedings, corrections, retractions, and other types of publications; 2) duplicate publications; and 3) publications with incomplete bibliographic information, such as title, country, authors, keywords, or source (Gao et al, 2023;Wang et al, 2023).…”

“…However, this bias is acceptable because our study aimed to elucidate the overall framework and development trajectory of research into lipid-lowering therapies for CHD in conjunction with hyperlipidemia. In future research, the comprehensiveness of our conclusions can be enhanced by expanding the list of search terms, extending the range of data sources, and incorporating a variety of analytical indicators (Wang et al, 2023).…”

Liver cancer from the perspective of single-cell sequencing: a review combined with bibliometric analysis

“…Therefore, a comprehensive review of scientific literature on the use of single-cell sequencing technologies in liver cancer research is essential to enhance our knowledge in this field. While some studies have provided systematic reviews and insights on the application of single-cell sequencing in liver cancer, they often lack objective visual data support, leading to issues such as subjectivity and heterogeneity (Wang et al 2024 ). Overcoming these challenges is crucial for a more thorough analysis, identification of research priorities, and defining innovative research directions (Wang et al 2024 ).…”

“…While some studies have provided systematic reviews and insights on the application of single-cell sequencing in liver cancer, they often lack objective visual data support, leading to issues such as subjectivity and heterogeneity (Wang et al 2024 ). Overcoming these challenges is crucial for a more thorough analysis, identification of research priorities, and defining innovative research directions (Wang et al 2024 ). Bibliometric analysis is a quantitative method used to assess scientific output, impact, and trends within a specific research field.…”