A Journey of Twenty-Five Years through the Ecological Biochemistry of Flavonoids

Tahara, Satoshi

doi:10.1271/bbb.70028

Cited by 129 publications

(79 citation statements)

References 15 publications

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“…lavonoids are one of the largest groups of plant secondary metabolites (1), and approximately 10,000 different flavonoids are known (2). They are synthesized by the phenylpropanoid pathways (1).…”

mentioning

confidence: 99%

Synthesis of Flavonoid O -Pentosides by Escherichia coli through Engineering of Nucleotide Sugar Pathways and Glycosyltransferase

Han

Kim

Yoon

et al. 2014

Appl Environ Microbiol

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Plants produce two flavonoid O-pentoses, flavonoid O-xyloside and flavonoid O-arabinoside. However, analyzing their biological properties is difficult because flavonoids are not naturally produced in sufficient quantities. In this study, Escherichia coli was used to synthesize the plant-specific flavonoid O-pentosides quercetin 3-O-xyloside and quercetin 3-O-arabinoside. Two strategies were used. First, E. coli was engineered to express components of the biosynthetic pathways for UDP-xylose and UDP-arabinose. For UDP-xylose biosynthesis, two genes, UXS (UDP-xylose synthase) from Arabidopsis thaliana and ugd (UDP-glucose dehydrogenase) from E. coli, were overexpressed. In addition, the gene encoding ArnA (UDP-L-Ara4N formyltransferase/UDPGlcA C-4؆-decarboxylase), which competes with UXS for UDP-glucuronic acid, was deleted. For UDP-arabinose biosynthesis, UXE (UDP-xylose epimerase) was overexpressed. Next, we engineered UDP-dependent glycosyltransferases (UGTs) to ensure specificity for UDP-xylose and UDP-arabinose. The E. coli strains thus obtained synthesized approximately 160 mg/liter of quercetin 3-O-xyloside and quercetin 3-O-arabinoside.

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confidence: 99%

Synthesis of Flavonoid O -Pentosides by Escherichia coli through Engineering of Nucleotide Sugar Pathways and Glycosyltransferase

Han

Kim

Yoon

et al. 2014

Appl Environ Microbiol

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“…In the 1980s, our laboratory discovered cochliophilin A, 5-hydroxy-6,7-methylenedioxyflavone, as a chemoattractant and a host-recognition signal compound toward the zoospores of A. cochlioides. 18) Recently, we also found a highly attractive response of A. cochlioides zoospores to cAMP, and an activator of AMP cyclase, forskolin, led to a two-fold increase of zoospore population density during the morphodifferentiation induction. In addition, 1 µM adenine in an A. cochlioides zoospore suspension cancelled the zoospore attraction toward cochliophilin A.…”

Section: Secondary Metabolites Produced By Pseudomonas Jessenii An Amentioning

confidence: 79%

Studies on the metabolic regulation of denitrifying bacteria and phytopathogenic microorganisms using chemical agents found in chemical ecology-based phenomena

Hashidoko

2018

J. Pestic. Sci.

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An interaction between two different living creatures is often mediated by a chemical substance, along with metabolic or morphological differentiation. Such phenomenon-based investigation of chemical substances sometimes leads to the discovery of a novel signaling substance associated with biological pest control, including pinpoint regulation of fundamental metabolisms. In studies on the metabolic regulation of denitrifying bacteria and phytopathogenic microorganisms, such chemicals linked to the introduction of new ideas and unique approaches for biorational pest controls are described.

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“…The total flavonoids and phenolic contents increased in Melilotus indicus and Lactuca sativa L. exposed to abiotic stresses (Ahmed et al, 2012;Rajabbeigi, et al, 2013). Flavonoids are efficient antioxidant (Tahara, 2007) and able to neutralize the reactive oxygen species under stress conditions (Gould, 2004), so nullify the stress injuries of Z. spinosa subjected to temporal and spatial variations. Tecomella undulate accumulated greater amount of flavonoids during summer season (Patel and Patel, 2014).…”

Section: Discussionmentioning

confidence: 99%

The Environmental Fluctuations of some Bioactive Nutraceutical Compounds in Zilla spinosa Inhabiting Arid Habitats

et al. 2017

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Zilla spinosa is one of the dominated woody perennial shrubs widespread in the Egyptian Red sea coastal desert, belonging to family Brassicacea. Z. spinosa is used as a folk medicine and for heating by local people. Z. spinosa inhabits arid habitats exposed to adverse climatic changes which influence the production of the bioactive natural products. The natural secondary products have significant importance for plant acclimatization to the arid habitats beside their significant practical application in medicinal, nutritive and industrial purposes. The accumulation levels of some natural products including phenols, tannins, glucosinolates, flavonoids, saponins, proanthocyanidins and cardiac glycosides were measured in Z. spinosa inhabiting different locations of Wadi Hagul during spring and summer seasons. The results of the current study showed that Z. spinosa grown in the adverse environment has adapted to cope with extreme temperature, water deficit and geoclimate changes especially in summer, by enhancing the accumulation of some antioxidant compounds including phenols, tannins, glucosinolates, flavonoids, saponins, cardiac glycosides, concomitant with increments in the total antioxidant capacity and PAL activity. Consequently, Z. spinosa shrubs inhabiting the arid environment is a promising new source of saponins, glucosinolates, cardiac glycosides, phenols and flavonoids which could participate in drug development and exploration of alternative strategies to increase productivity of wild plants.

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A Journey of Twenty-Five Years through the Ecological Biochemistry of Flavonoids

Cited by 129 publications

References 15 publications

Synthesis of Flavonoid O -Pentosides by Escherichia coli through Engineering of Nucleotide Sugar Pathways and Glycosyltransferase

Synthesis of Flavonoid O -Pentosides by Escherichia coli through Engineering of Nucleotide Sugar Pathways and Glycosyltransferase

Studies on the metabolic regulation of denitrifying bacteria and phytopathogenic microorganisms using chemical agents found in chemical ecology-based phenomena

The Environmental Fluctuations of some Bioactive Nutraceutical Compounds in Zilla spinosa Inhabiting Arid Habitats

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