A journey through formation and malformations of the neo-cortex

Reghunath, Anjuna; Ghasi, Rohini Gupta

doi:10.1007/s00381-019-04429-0

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…Gray matter clusters are seen in localizations that should not be in the brain. The incidence of epilepsy is very high in patients with gray matter heterotopia [11][12][13][14][15]. The most common subtype is SEH.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Apparent Diffusion Coefficient Values of White Matter Surrounding the Heterotopia in Children With Unilateral Subependymal Heterotopia

Eroğlu¹,

Kara²

2022

Cureus

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Introduction: To compare the apparent diffusion coefficient (ADC) values of the white matter around heterotopia in children with unilateral subependymal heterotopia with those of the symmetrical normal cerebral hemisphere and control group.Methods: Between January 2011 and September 2021, 15 pediatric patients with unilateral focal subependymal heterotopia among 47 patients with heterotopia detected in brain magnetic resonance imaging (MRI) in our hospital were included in the study. The control group consisted of 15 age-and sexmatched children with normal neurological examination and normal brain MRI. In brain MRIs, ADC value was measured from the white matter around the heterotopia area and from the opposite cerebral hemisphere matched to the location, and from the bilateral location-matched white matter of the control group. The area of heterotopia was measured on axial T1-weighted MRI. The data were evaluated statistically.Results: There were eight girls and seven boys in the heterotopia group. The median age was 5.00 (min: 3, max: 14). There was no statistically significant difference between the ADC values of the heterotopia side and contralateral white matter of the heterotopia group. In addition, no statistically significant difference was found between the heterotopia side and opposite sides of the heterotopia and control groups ADC values.Conclusion: According to the findings of this study, no difference was found in the ADC values of the white matter around the lesion in children with subependymal heterotopia compared to the opposite cerebral hemisphere and control groups.

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Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Apparent Diffusion Coefficient Values of White Matter Surrounding the Heterotopia in Children With Unilateral Subependymal Heterotopia

Eroğlu¹,

Kara²

2022

Cureus

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“…Hemimegalencephaly (HME) is a rare congenital malformation of cortical development (MCD) characterized by enlarged and dysplastic hamartomatous overgrowth of one or all parts of a cerebral hemisphere [1,2]. HME may be present in isolation or conjunction with other neurocutaneous syndromes such as epidermal nevus, Klippel-Trénauany-Weber syndrome, neurofibromatosis type 1, hypomelanosis of Ito, Proteus syndrome, or more rarely, tuberous sclerosis [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Clinical manifestations of HME and other MCDs vary depending on the severity of the malformation, and they commonly present as medical refractory epilepsy and cognitive impairment in the pediatric population and are rarely reported in the adult population [ 3 , 7 ]. Other clinical manifestations could be early feeding problems, infantile spasm, macrocephalus, hydrocephalus, and mild hemiparesis [ 2 ]. Most commonly, HME affects an entire hemisphere, but localized forms have also been reported in the literature, with the most notable being posterior quadrantic dysplasia (PQD) or hemi-HME with an enlargement of the parieto-occipito-temporal lobe, sparing the frontal lobe of a single hemisphere [ 4 , 8 - 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most commonly, HME affects an entire hemisphere, but localized forms have also been reported in the literature, with the most notable being posterior quadrantic dysplasia (PQD) or hemi-HME with an enlargement of the parieto-occipito-temporal lobe, sparing the frontal lobe of a single hemisphere [ 4 , 8 - 11 ]. Dysmorphic ipsilateral occipital horn with high-signal posterior periventricular white matter and abnormal gyri can be observed in most patients with PQD [ 2 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Hemi-Hemimegalencephaly or Posterior Quadrantic Dysplasia, a Rare Cause of Focal Epilepsy in an Otherwise Healthy Young Woman: A Case Report

Feidert¹

2020

Cureus

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Hemimegalencephaly (HME) and its more localized form-posterior quadrantic dysplasia (PQD)-are rare malformations of cortical development (MCD) that normally manifest as refractory focal epilepsy and cognitive impairment in children. We report a case study of a 19-year-old woman who presented with seizure-like symptoms to the emergency department after discontinuing her seizure treatment having fled her country. MRI revealed typical signs of PQD. This case study demonstrates how an unusual mild clinical presentation led to the late diagnosis of this rare MCD.

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A journey through formation and malformations of the neo-cortex

Cited by 8 publications

References 26 publications

Comparative Evaluation of Apparent Diffusion Coefficient Values of White Matter Surrounding the Heterotopia in Children With Unilateral Subependymal Heterotopia

Comparative Evaluation of Apparent Diffusion Coefficient Values of White Matter Surrounding the Heterotopia in Children With Unilateral Subependymal Heterotopia

Hemi-Hemimegalencephaly or Posterior Quadrantic Dysplasia, a Rare Cause of Focal Epilepsy in an Otherwise Healthy Young Woman: A Case Report

Infantile epileptic spasms syndrome in a child with lissencephaly associated with de novo PAFAH1B1 variant and coincidental CMV infection

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