A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

Vauthier, Christine

doi:10.1080/1061186x.2019.1588280

Cited by 26 publications

(23 citation statements)

References 374 publications

(472 reference statements)

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“…Due to their unique characteristics, NPs can increase solubility, circulation time and bioavailability of a drug, promoting a greater accumulation at the target site. Nonetheless, efficient drug delivery requires both internalization of the drug-loaded NP and release of the drug once internalized (Vauthier 2019). One key feature of NPs is their increased surface area to volume ratio, altering the material's mechanical, thermal and catalytic properties compared to known bulk properties.…”

Section: Discussionmentioning

confidence: 99%

“…The general purpose of a drug carrier is to provide the drug with a more appropriate or attractive pharmacokinetic and biodistribution profile, promoting biological efficacy and reducing side effects by giving a more efficient distribution at the target site (Vauthier 2019). This may be achieved by exploiting the unique properties of NPs.…”

Section: Nanoparticles In Drug Deliverymentioning

confidence: 99%

“…In the infancy of the research field in the early 1970s, small vesicles called liposomes were used to encapsulate and improve the performance of existing drugs. As opposed to covalently linking the active ingredient to its carrier, entrapment within a vesicle kept the chemical structure unaltered and allowed for more molecules to be packaged within each vesicle (Vauthier 2019).…”

Section: Nanoparticles In Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death

et al. 2019

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First and foremost, I would like to thank my main supervisor Maria L. Torgersen for asking me to come back to the department to do my PhD. We had worked very well together when I was an engineer in Kirsten's group, and the thought of continuing that collaboration and learning process was attractive. You have been a dedicated and steady project leader, you love your work and transmit your passion while working side-by-side in the lab, you are meticulous and always think two steps ahead. Thank you for guiding me through this work.I would also like to express my gratitude to Kirsten Sandvig, as my co-supervisor and former group leader, and Harald Stenmark, as my current group leader. You have both provided a comfortable and motivating work environment, inspiration, help and insight.I would like to acknowledge all my co-authors for excellent collaboration. A special thanks goes to Marzena Szwed for being so much more than a co-author. Working together with you was always a pleasure. To Nikolai Engedal, for your interesting ideas and opinions on autophagy. To Tore Skotland, Anders Øverbye and Tore-Geir Iversen, for advice and guidance in the world of nanoparticles.I would sincerely like to thank all the people that have made these years working in the lab fun and enjoyable. We have shared more than frustrations over experiments and the joy of good results. I cherish the time spent in your company and thank you for all the great conversations and dinner parties. Although I will miss you in everyday life, I truly appreciate the fact that our friendship extends far beyond the lab. Sascha, you are the best officemate I could ever have asked for. Your laughter is contagious, you join me for a little dance or song, you listen when I talk, and you care. Ulrikke and Maja, you are the sunshine of my workday. I'm extremely grateful for having your friendship at work, you are always compassionate and helpful. Work would be harder without your supportive smiles and encouraging words. Anthony and Andreas, thank you for all the coffee and ice-cream breaks, and for discussions not only regarding work but of life in general. You´re always supportive, full of life and leave me in a good mood. Chema, thank you for being so much more than technical support. You come with fresh pastry on the weekends, engage in birthday celebrations and provide support when needed. Marta, Krizia, Domenica, Maria, Marzena, you left the lab and the country, but never the heart. Thank you for choosing MCB as your place to go abroad. I miss having you around and look forward to we can travel and see each other again. The boot camp crew: Simona, Helene, Viola, Maxi-Lu, Silvana and Kia Wee, Wednesday nights will not be the same without your happy faces. Suffering together as Viola pushes for the next exercise, knowing that we all dream for the same VI delicious smell of Indian food that awaits with Kay. Thank you for always listening and encouraging me. It has become a highlight of my week. Anne-Grethe, chatting with you has always been entertaining. Anne and ...

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Section: Discussionmentioning

confidence: 99%

Section: Nanoparticles In Drug Deliverymentioning

confidence: 99%

Section: Nanoparticles In Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death

et al. 2019

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“…Poly(alkylcyanoacrylate) nanoparticles and nanoparticles containing copolymers with poly(alkylcyanoacrylate) blocks were used as carriers of bioactive substances. Here we cite only some original papers published during the last ten years [ 116 , 117 , 118 , 119 , 120 ] and some comprehensive reviews covering this subject [ 121 , 122 , 123 , 124 , 125 , 126 ].…”

Section: Polymers For Preparation Of Drug Delivery Carriersmentioning

confidence: 99%

“…Nucleic acids from well-defined living organisms not only are too expensive to be used on a large scale for drug encapsulation but, what is even more im- Poly(alkylcyanoacrylate) nanoparticles and nanoparticles containing copolymers with poly(alkylcyanoacrylate) blocks were used as carriers of bioactive substances. Here we cite only some original papers published during the last ten years [116][117][118][119][120] and some comprehensive reviews covering this subject [121][122][123][124][125][126].…”

Section: Biopolymersmentioning

confidence: 99%

Functionalized Particles Designed for Targeted Delivery

et al. 2021

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Pure bioactive compounds alone can only be exceptionally administered in medical treatment. Usually, drugs are produced as various forms of active compounds and auxiliary substances, combinations assuring the desired healing functions. One of the important drug forms is represented by a combination of active substances and particle-shaped polymer in the nano- or micrometer size range. The review describes recent progress in this field balanced with basic information. After a brief introduction, the paper presents a concise overview of polymers used as components of nano- and microparticle drug carriers. Thereafter, progress in direct synthesis of polymer particles with functional groups is discussed. A section is devoted to formation of particles by self-assembly of homo- and copolymer-bearing functional groups. Special attention is focused on modification of the primary functional groups introduced during particle preparation, including introduction of ligands promoting anchorage of particles onto the chosen living cell types by interactions with specific receptors present in cell membranes. Particular attention is focused on progress in methods suitable for preparation of particles loaded with bioactive substances. The review ends with a brief discussion of the still not answered questions and unsolved problems.

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Nano‐Oncologicals: A Tortoise Trail Reaching New Avenues

Dacoba

Anthiya

Berrecoso

et al. 2021

Adv Funct Materials

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Research efforts towards cancer therapeutics have resulted in the development of a variety of pharmacological molecules, including small synthetic molecules and biological drugs (RNA-based therapies and monoclonal antibodies-mAbs), intended to target tumor or immune-related cells, or their signaling mediators. The majority of them present important biopharmaceutical problems related to their difficulties for overcoming biological barriers and reach their targets. Nanotechnology has been, for more than 60 years, trying to solve these problems. As knowledge in drug discovery, molecular biology, and biomaterials advances, there has been significant progress in the adequate design of nanodelivery strategies that may significantly contribute to the exploitation of the new therapies. This review provides a critical overview of the current potential of nanotechnology to solve problems associated with the different categories of drugs. Starting with the general concept of passive and active targeting, it presents the distinct advantages that delivery technologies have shown to date for improving the therapeutic outcome of small drugs with cytotoxic activity, RNA-and mAb-based therapies. Moreover, it precisely describes the benefits of combining immunotherapies and nanotechnology. The most advanced technologies are put into perspective in relation to their translational pathway and the future avenues for nano-oncologicals.

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A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

Cited by 26 publications

References 374 publications

Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death

Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death

Functionalized Particles Designed for Targeted Delivery

Nano‐Oncologicals: A Tortoise Trail Reaching New Avenues

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