A journey to understand wheat Fusarium head blight resistance in the Chinese wheat landrace Wangshuibai

Jia, Haiyan; Zhou, Jianglin; Xue, Shulin; Li, Guoqiang; Yan, Haisheng; Ran, Congfu; Zhang, Yiduo; Shi, Jinxing; Li, Jia; Wang, Xin; Luo, Jing; Ma, Zhengqiang

doi:10.1016/j.cj.2017.09.006

Cited by 94 publications

(84 citation statements)

References 91 publications

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“…From more than 250 documented QTL conferring FHB resistance, only Fhb1-Fhb7 haved been proven to be major effects QTLs. Qfhs.nau-6B (Fhb2), Qfhi.nau-4B (Fhb4), and Qfhi.nau-5A (Fhb5) were fine mapped in the 2.2 cM, 0.14 cM, and 0.09 cM interval [16]. Fhb1 has been cloned recently [18][19][20].…”

Section: Fhb Resistance Loci Identified By Gwasmentioning

confidence: 99%

“…Resistance to F. graminearum in wheat has been classified into five categories: (1) type I for resistance to initial infection by the pathogen, (2) type II for resistance to fungal spread along the rachis, (3) type III for resistance to kernel infection, (4) type IV for resistance to toxin accumulation, and (5) type V for tolerance [12,13]. Many quantitative trait loci (QTL) have been identified for multiple types of FHB resistance in wheat with different magnitudes of effects [14][15][16][17]. Major and stable QTL often have large effects in multiple environments and are more valuable for practical breeding than minor QTL.…”

Section: Introductionmentioning

confidence: 99%

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Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Gao

et al. 2020

BMC Plant Biol

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Background: Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is a major threat to wheat production and food security worldwide. Breeding stably and durably resistant cultivars is the most effective approach for managing and controlling the disease. The success of FHB resistance breeding relies on identification of an effective resistant germplasm. We conducted a genome-wide association study (GWAS) using the highdensity wheat 90 K single nucleotide polymorphism (SNP) assays to better understand the genetic basis of FHB resistance in natural population and identify associated molecular markers.Results: The resistance to FHB fungal spread along the rachis (Type II resistance) was evaluated on 171 wheat cultivars in the 2016-2017 (abbr. as 2017) and 2017-2018 (abbr. as 2018) growing seasons. Using Illumina Infinum iSelect 90 K SNP genotyping data, a genome-wide association study (GWAS) identified 26 loci (88 marker-trait associations), which explained 6.65-14.18% of the phenotypic variances. The associated loci distributed across all chromosomes except 2D, 6A, 6D and 7D, with those on chromosomes 1B, 4A, 5D and 7A being detected in both years. New loci for Type II resistance were found on syntenic genomic regions of chromsome 4AL (QFhb-4AL, 621.85-622.24 Mb) and chromosome 5DL (QFhb-5DL, 546.09-547.27 Mb) which showed high collinearity in gene content and order. SNP markers wsnp_JD_c4438_5568170 and wsnp_CAP11_c209_198467 of 5D, reported previously linked to a soil-borne wheat mosaic virus (SBWMV) resistance gene, were also associated with FHB resistance in this study. Conclusion: The syntenic FHB resistant loci and associated SNP markers identified in this study are valuable for FHB resistance breeding via marker-assisted selection.

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Section: Fhb Resistance Loci Identified By Gwasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Gao

et al. 2020

BMC Plant Biol

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“…PFT is predicted to encode a chimeric lectin with two agglutinin domains and an ETX/MTX2 toxin domain. However, the role of PFT in FHB resistance is still disputed (Jia et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Bikram Gill and colleagues performed map-based cloning to identify Fhb1 candidate genes and found that pore-forming toxin-like (PFT) confers FHB resistance by mutation analysis, gene silencing, and transgenic overexpression in wheat (Rawat et al 2016). PFT is predicted to encode a chimeric lectin with two agglutinin domains and an EXT/ MTX2 toxin domain (Rawat et al 2016), although this finding is still in dispute (Jia et al 2018). Additional investigation of PFT is necessary to fully understand Fhb1 and allow the design of robust markers for marker-assisted breeding, gene pyramiding, and genetic engineering to provide a long-term, economical solution to FHB outbreaks.…”

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confidence: 99%

Molecular Characterization and Expression of PFT, an FHB Resistance Gene at the Fhb1 QTL in Wheat

Zhang

Zhuo

et al. 2018

Phytopathology®

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Fusarium head blight (FHB) is a destructive fungal disease in wheat worldwide. Efforts have been carried out to combat this disease, and the pore-forming toxin-like (PFT) gene at the quantitative trait locus (QTL) Fhb1 was isolated and found to confer resistance to FHB in Sumai 3. In this study, we characterized PFT in 348 wheat accessions. Four haplotypes of PFT were identified. The wild haplotype of PFT had higher resistance than other haplotypes and explained 13.8% of phenotypic variation in FHB resistance by association analysis. PFT was highly expressed during early flowering and increased after Fusarium graminearum treatment in Sumai 3. Analysis of the 5' flanking sequence of PFT predicted that the cis elements of the PFT promoter were related to hormones and biological defense responses. However, PFT existed not only in the FHB-resistant accessions but also in some susceptible accessions. These results suggested that FHB resistance in a diverse range of wheat genotypes is partially conditioned by PFT. The profiling of FHB resistance and the PFT locus in this large collection of wheat germplasm may prove helpful for incorporating FHB resistance into wheat breeding programs, although more work is needed to reveal the exact role of the QTL Fhb1 in conferring resistance to fungal spread.

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“…From more than 250 documented QTL conferring FHB resistance, only Fhb1-Fhb7 haved been proven to be major effects QTLs. Qfhs.nau-6B (Fhb2), Qfhi.nau-4B (Fhb4), and Qfhi.nau-5A (Fhb5) were successfully fine mapped in the 2.2 cM, 0.14 cM, and 0.09 cM interval [16]. Fhb1 has been cloned recently [18][19][20].…”

Section: Fhb Resistance Loci Identified By Gwasmentioning

confidence: 99%

Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Hu¹,

Gao²,

Wu³

et al. 2019

Preprint

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Background: Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is a major threat to wheat production and food security worldwide. Breeding stably and durably resistant cultivars is the most effective approach for managing and controlling the disease. The success of FHB resistance breeding relies on identification of an effective resistant germplasm. We performed a genome-wide association study (GWAS) using the high-density wheat 90K single nucleotide polymorphism (SNP) assays to better understand the genetic basis of FHB resistance in natural population and identify associated molecular markers. Results: The resistance to FHB fungal spread along the rachis (Type II resistance) was evaluated on 171 wheat cultivars in the 2016-2017 (abbr. as 2017) and 2017-2018 (abbr. as 2018) growing seasons. Using Illumina Infinum iSelect 90K SNP genotyping data, a genome-wide association study (GWAS) identified 26 loci (88 marker-trait associations), which explained 6.65-14.18% of the phenotypic variances. The associated loci distributed across all chromosomes except 2D, 6A, 6D and 7D, with those on chromosomes 1B, 4A, 5D and 7A being detected in both years. New loci for Type II resistance were found on syntenic genomic regions of chromsome 4AL (QFhb-4AL, 621.85-622.24 Mb) and chromosome 5DL (QFhb-5DL, 546.09-547.27 Mb) which showed high collinearity in gene content and order. SNP markers wsnp_JD_c4438_5568170 and wsnp_CAP11_c209_198467 of 5D, reported previously linked to a soil-borne wheat mosaic virus (SBWMV) resistance gene, were also associated with FHB resistance in this study. Conclusion: The syntenic FHB resistant loci and associated SNP markers identified in this study are valuable for FHB resistance breeding via marker-assisted selection.

show abstract

A journey to understand wheat Fusarium head blight resistance in the Chinese wheat landrace Wangshuibai

Cited by 94 publications

References 91 publications

Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Molecular Characterization and Expression of PFT, an FHB Resistance Gene at the Fhb1 QTL in Wheat

Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

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