A KaiC-Interacting Sensory Histidine Kinase, SasA, Necessary to Sustain Robust Circadian Oscillation in Cyanobacteria

Iwasaki, Hideo; Williams, Stanly B.; Kitayama, Yohko; Ishiura, Masahiro; Golden, Susan S.; Kondo, Takao

doi:10.1016/s0092-8674(00)80832-6

Cited by 249 publications

(288 citation statements)

References 33 publications

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“…One example of these sensors is His kinase 8 (Hik8), a homolog of SasA from Synechococcus that interacts with KaiC, a protein that is involved in circadian control (Iwasaki et al, 2000) and allows cells to grow under heterotrophic growth conditions probably via the regulation of gap1 transcription (Singh and Sherman, 2005). It is also known that Hik31 regulates Glc catabolism in Synechocystis either via the transcriptional regulation of the icfG (slr1860) gene that encodes a protein Ser phosphatase or by modulation of Glk activity (Kahlon et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Regulation of the Respiratory Genes in the CyanobacteriumSynechocystissp. PCC 6803 during the Early Response to Glucose Feeding

et al. 2007

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The coordinated expression of the genes involved in respiration in the photosynthetic cyanobacterium Synechocystis sp. PCC 6803 during the early period of glucose (Glc) treatment is poorly understood. When photoautotrophically grown cells were supplemented with 10 mM Glc in the light or after a dark adaptation period of 14 h, significant increases in the respiratory activity, as determined by NAD(P)H turnover, respiratory O 2 uptake rate, and cytosolic alkalization, were observed. At the same time, the transcript levels of 18 genes coding for enzymes associated with respiration increased with differential induction kinetics; these genes were classified into three groups based on their half-rising times. Transcript levels of the four genes gpi, zwf, pdhB, and atpB started to increase along with a net increase in NAD(P)H, while the onset of net NAD(P)H consumption coincided with an increase in those of the genes tktA, ppc, pdhD, icd, ndhD2, ndbA, ctaD1, cydA, and atpE. In contrast, the expression of the atpI/G/D/A/C genes coding for ATP synthase subunits was the slowest among respiratory genes and their expression started to accumulate only after the establishment of cytosolic alkalization. These differential effects of Glc on the transcript levels of respiratory genes were not observed by inactivation of the genes encoding the Glc transporter or glucokinase. In addition, several Glc analogs could not mimic the effects of Glc. Our findings suggest that genes encoding some enzymes involved in central carbon metabolism and oxidative phosphorylation are coordinately regulated at the transcriptional level during the switch of nutritional mode.Respiration releases the energy stored in carbon compounds and also provides many carbon precursors for the biosynthesis of a wide variety of plant biomolecules, including amino acids, lipids, isoprenoids, and porphyrins. D-Glc (hereafter Glc) is an immediate substrate for the four major respiration processes: glycolysis, the oxidative pentose phosphate (OPP) pathway, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation. In plants, respiration is predominantly controlled by the key metabolites ADP and inorganic phosphate, and the ratio of NADPH to NADP 1 . The cellular concentration of ADP initially controls the rates of electron transfer and ATP synthesis, which in turn affect TCA cycle activity, finally resulting in the regulation of glycolytic reactions.

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Section: Discussionmentioning

confidence: 99%

Transcriptional Regulation of the Respiratory Genes in the CyanobacteriumSynechocystissp. PCC 6803 during the Early Response to Glucose Feeding

et al. 2007

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“…The third division is an output pathway that relays temporal information from the oscillator to a variety of downstream biochemical processes in diverse organisms (4). In S. elongatus, the kinase SasA acts close to the oscillator in an output pathway (10,11).…”

Section: Ircadian Rhythms Are Oscillations Of Biological Activitiesmentioning

confidence: 99%

Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock

Ivleva¹,

Gao

LiWang

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

108

148

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Circadian rhythms are endogenous cellular programs that time metabolic and behavioral events to occur at optimal times in the daily cycle. Light and dark cycles synchronize the endogenous clock with the external environment through a process called entrainment. Previously, we identified the bacteriophytochrome-like circadian input kinase CikA as a key factor for entraining the clock in the cyanobacterium Synechococcus elongatus PCC 7942. Here, we present evidence that CikA senses not light but rather the redox state of the plastoquinone pool, which, in photosynthetic organisms, varies as a function of the light environment. Furthermore, CikA associates with the Kai proteins of the circadian oscillator, and it influences the phosphorylation state of KaiC during resetting of circadian phase by a dark pulse. The abundance of CikA varies inversely with light intensity, and its stability decreases in the presence of the quinone analog 2,5-dibromo-3-methyl-6-isopropylp-benzoquinone (DBMIB). The pseudo-receiver domain of CikA is crucial for sensitivity to DBMIB, and it binds the quinone directly, a demonstration of a previously unrecognized ligand-binding role for the receiver fold. Our results suggest that resetting the clock in S. elongatus is metabolism-dependent and that it is accomplished through the interaction of the circadian oscillator with CikA.biological rhythms ͉ photosynthetic electron transport ͉ pseudo-receiver ͉ redox ͉ Synechococcus elongatus

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“…In the simpler systems, without kaiA, other yet-unknown gene(s) may play the role. Indeed, even the three-gene kai system includes other, either homologous to kai or not, genes essential for the circadian regulation (36,37). Such genes may be elements of the simpler systems ensuring their functionality.…”

Section: Evolution Of Kai Genes and Geological History Of The Earthmentioning

confidence: 99%

Origin and evolution of circadian clock genes in prokaryotes

Dvornyk

Vinogradova²,

Nevo³

2003

Proc. Natl. Acad. Sci. U.S.A.

224

204

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Regulation of physiological functions with approximate daily periodicity, or circadian rhythms, is a characteristic feature of eukaryotes. Until recently, cyanobacteria were the only prokaryotes reported to possess circadian rhythmicity. It is controlled by a cluster of three genes: kaiA, kaiB, and kaiC. Using sequence data of Ϸ70 complete prokaryotic genomes from the various public depositories, we show here that the kai genes and their homologs have quite a different evolutionary history and occur in Archaea and Proteobacteria as well. Among the three genes, kaiC is evolutionarily the oldest, and kaiA is the youngest and likely evolved only in cyanobacteria. Our data suggest that the prokaryotic circadian pacemakers have evolved in parallel with the geological history of the earth, and that natural selection, multiple lateral transfers, and gene duplications and losses have been the major factors shaping their evolution.

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A KaiC-Interacting Sensory Histidine Kinase, SasA, Necessary to Sustain Robust Circadian Oscillation in Cyanobacteria

Cited by 249 publications

References 33 publications

Transcriptional Regulation of the Respiratory Genes in the CyanobacteriumSynechocystissp. PCC 6803 during the Early Response to Glucose Feeding

Transcriptional Regulation of the Respiratory Genes in the CyanobacteriumSynechocystissp. PCC 6803 during the Early Response to Glucose Feeding

Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock

Origin and evolution of circadian clock genes in prokaryotes

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