In this paper, we focus on the development and study of the finite difference/pseudo-spectral method to obtain an approximate solution for the time-fractional diffusion-wave equation in a reproducing kernel Hilbert space. Moreover, we make use of the theory of reproducing kernels to establish certain reproducing kernel functions in the aforementioned reproducing kernel Hilbert space. Furthermore, we give an approximation to the time-fractional derivative term by applying the finite difference scheme by our proposed method. Over and above, we present an appropriate technique to derive the numerical solution of the given equation by utilizing a pseudo-spectral method based on the reproducing kernel. Then, we provide two numerical examples to support the accuracy and efficiency of our proposed method. Finally, we apply numerical experiments to calculate the quality of our approximation by employing discrete error norms.