2009
DOI: 10.1523/jneurosci.1822-09.2009
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A Key Role for gp130 Expressed on Peripheral Sensory Nerves in Pathological Pain

Abstract: Interleukin-6 (IL-6) is a key mediator of inflammation. Inhibitors of IL-6 or of its signal transducing receptor gp130 constitute a novel class of anti-inflammatory drugs, which raise great hopes for improved treatments of painful inflammatory diseases such as rheumatoid arthritis. IL-6 and gp130 may enhance pain not only indirectly through their proinflammatory actions but also through a direct action on nociceptors (i.e., on neurons activated by painful stimuli). We found indeed that the IL-6/gp130 ligand-re… Show more

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Cited by 140 publications
(149 citation statements)
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“…They are activated or modulated by a range of algogenic mediators released during tissue damage, including ATP, bradykinin, glutamate, chemicals from mast cells (including mast cell proteases), nerve growth factor, prostaglandins, histamine and 5-hydroxytryptamine 106a . They also have receptors for key inflammatory cytokines including IL-1β, 107 IL-6 108 and TNF. 109 The excitability of these neurons is profoundly modulated during experimental inflammation, particularly in the post-inflammatory period.…”
Section: Vascular Afferents: Activation By Mediatorsmentioning
confidence: 99%
“…They are activated or modulated by a range of algogenic mediators released during tissue damage, including ATP, bradykinin, glutamate, chemicals from mast cells (including mast cell proteases), nerve growth factor, prostaglandins, histamine and 5-hydroxytryptamine 106a . They also have receptors for key inflammatory cytokines including IL-1β, 107 IL-6 108 and TNF. 109 The excitability of these neurons is profoundly modulated during experimental inflammation, particularly in the post-inflammatory period.…”
Section: Vascular Afferents: Activation By Mediatorsmentioning
confidence: 99%
“…Some tumours produce interleukin-6 [144] and elevation of serum IL-6 levels is found in up to 60 % of lung cancer patients in advanced stages [145]. Mice with a selective deletion of the signal transducer protein gp130 in neurons develop significantly reduced levels of inflammatory and tumour-induced pain independent of the degree of inflammation or tumour growth [146]. In addition, IL-6 sensitises peripheral nociceptors to mechanical stimuli [147].…”
Section: Interleukin-6mentioning
confidence: 99%
“…A dual regulation of heat sensitivity by IL-6 and its soluble receptor sIL-6R has been reported [156]. The sensitization involves activation of the Janus tyrosine kinase (Jak), the adapter proteins Gab1 and Gab2 and finally PKC-delta which regulates the heat transducer ion channel TRPV1 [134,146]. Currently, the launch of inhibitors IL-6 or gp130 as a novel class of antiinflammatory drugs not only gives rise to great hopes for the treatment of inflammation in rheumatoid arthritis [157][158][159] but may also alleviate its most quality of life worsening symptom, pain.…”
Section: Interleukin-6mentioning
confidence: 99%
“…Furthermore, peripheral injury-induced IL-6 is able to promote regeneration within the CNS (Cafferty et al, 2004;Cao et al, 2006). Since the IL-6 signal-transducing ␤ receptor, gp130, is ubiquitously expressed in sensory neurons, the specificity of IL-6 signaling is mainly mediated by tissue-specific constitutive IL-6 ␣ receptor, IL-6R, expression and/or local actions of soluble IL-6R (Gardiner et al, 2002;Andratsch et al, 2009). Although the effects of IL-6 are well established in nerve regeneration, the cellular expression of IL-6R in the dorsal root ganglia is unknown.…”
Section: Introductionmentioning
confidence: 99%