This study focused on the intelligent model for ore pulp density in the hydrometallurgical process. However, owing to the limitations of existing instruments and devices, the feed ore pulp density of thickener, a key hydrometallurgical equipment, cannot be accurately measured online. Therefore, aiming at the problem of accurately measuring the feed ore pulp density, we proposed a new intelligent model based on the long short-term memory (LSTM) and hybrid genetic algorithm (HGA). Specifically, the HGA refers to a novel optimization search algorithm model that can optimize the hyperparameters and improve the modeling performance of the LSTM. Finally, the proposed intelligent model was successfully applied to an actual thickener case in China. The intelligent model prediction results demonstrated that the hybrid model outperformed other models and satisfied the measurement accuracy requirements in the factory well.