It is encouraged that designers should explore in wide multi-disciplinary solution spaces for finding novel and promising principle solutions to desired functions during conceptual design. However, due to lack of sufficient multi-disciplinary knowledge, it is often difficult for human designers to explore in wide multi-disciplinary solution spaces. Therefore, this paper proposes a multi-agent-based approach for assisting designers in achieving multi-disciplinary conceptual design synthesis. The roles of different kinds of designing agents are identified, and the collaborative mechanisms among these agents are also elaborated. The conceptual design test case of a solar toy demonstrates that the proposed multiagent-based design synthesis approach, compared with our previous approach, can achieve higher efficiency and better robustness through collaborative conceptual design synthesis.