A label-free detection of diethylstilbestrol based on molecularly imprinted polymer-coated upconversion nanoparticles obtained by surface grafting

Wang, Yu; Ren, Shuyue; Jiang, Huicong; Peng, Yuan; Bai, Jintao; Li, Qiaofeng; Li, Chao; Gao, Zhixian; Ning, Baoan

doi:10.1039/c6ra26999k

Cited by 15 publications

(13 citation statements)

References 32 publications

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“…Wang et al [118] reported a sensor selective to diethylbestrol based on MIP-coated UCNPs (NaYF 4 :Yb,Er). They covered the NPs with silica and functionalized with MPS so that polymerization on the surface could be controlled.…”

Section: Three-dimensional Compositesmentioning

confidence: 99%

“…However, they are of great interest due to their synthetic versatility and the large number of functional groups with which they can be functionalized [160]. This fact has been reflected in other nanocomposites in which the main core has been covered with silica in order to improve its properties or to allow a controlled polymerization [118]. This section shows some examples where SiO 2 is the fundamental core of nanocomposites (Table 9).…”

Section: Three-dimensional Compositesmentioning

confidence: 99%

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Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Rico-Yuste¹,

Carrasco

2019

Polymers

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We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.

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Section: Three-dimensional Compositesmentioning

confidence: 99%

Section: Three-dimensional Compositesmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Rico-Yuste¹,

Carrasco

2019

Polymers

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“…To measure the adsorption capacity of the two MMIPs, 0.05 g of MMIPs/MNIPs was added to 5 mL of 100 μg mL −1 DES in acetonitrile. The mixture was mechanically shaken for various times (1,3,5,7,9,10,11,13 min) at room temperature. After the MMIP/MNIP sorbent had separated under an external magnet, the supernatant was analyzed using HPLC.…”

Section: Adsorption Kinetics Experimentsmentioning

confidence: 99%

“…Diethylstilbestrol (DES), a type of synthetic estrogen medication, is widely used as a growth stimulant in animal husbandry and in the treatment of pregnancy complications. 1 DES, which can be bio-accumulated in the human body through the food chain, can interfere with the synthesis and release of normal secretions, and activate or inhibit the function of the endocrine system, resulting in disorder of metabolism regulation. 2,3 Numerous methods have been developed for the detection of DES in foods, such as immunoassay, 4 electrochemistry, [5][6][7][8][9] gas chromatography, 10 high-performance liquid chromatography (HPLC), 11 gas chromatography-mass spectrometry 12 and HPLC-mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Preparation of magnetic molecularly imprinted polymers for the rapid detection of diethylstilbestrol in milk samples

Huang

Zhao

2019

J Sci Food Agric

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BACKGROUND: Diethylstilbestrol (DES) residues are harmful to human health because of their potential carcinogenic properties. Therefore, it is important to develop a fast and efficient pretreatment method to prevent their harmful effects on human health and the environment. RESULTS: In this paper, two types of magnetic molecularly imprinted polymers (MMIPs) of DES were prepared by bulk polymerization and the sol-gel method, respectively. The synthetic materials were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis. Adsorption capacities of the bulk and sol-gel MMIPs were investigated. A rapid detection method was developed using the two types of MMIPs as sorbents, coupled to high-performance liquid chromatography, for the determination of DES residues in milk samples. Under optimized conditions, the limit of detection (S/N = 3) of both methods for DES was 2.0 g L −1 ; and the linear response range to DES was 0.1-500 mg L −1 . The milk samples were analyzed according to this method with good recoveries of 88.3-97.6 and 90.5-103.5% for the two types of MMIPs, respectively. CONCLUSIONS: The method described had high sensitivity and high selectivity, and could prove to be a new method for the rapid determination of DES residues in milk samples.where C 0 (μg mL −1 ) is the initial concentration of DES in acetonitrile solution, C (μg mL −1 ) is the equilibrium concentration of DES in acetonitrile solution, V (mL) is the volume of solution and W is the mass of MMIPs/MNIPs (g).J Sci Food Agric 2019; 99: 4452-4459Adsorption kinetics experiments Figure 6 shows the adsorption isotherms of MMIPs and MNIPs for DES prepared by bulk polymerization and the sol-gel method. The adsorption capacity of bulk and sol-gel MMIPs for DES increased J Sci Food Agric 2019; 99: 4452-4459

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“…As it was shown, NP-labelled antibodies in combination with ICP-MS used in dot-blot analysis are providing 4 orders of magnitude improved detection limits compared to standard metal-based labelling approach 31 . The idea of MIP-based technology has been employed in combination with nanoparticles (NPs) made of Fe 3 O 4 32,33 , gold NPs 34 , CuO NPs 35 , EuS NPs 36 , quantum dots 37–44 and upconversion NPs 45,46 .…”

Section: Introductionmentioning

confidence: 99%

CdS quantum dots-based immunoassay combined with particle imprinted polymer technology and laser ablation ICP-MS as a versatile tool for protein detection

Vaněčková

Bezděková

Tvrdoňová

et al. 2019

Sci Rep

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For the first time, the combination of molecularly imprinted polymer (MIP) technology with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is presented with focus on an optimization of the LA-ICP-MS parameters such as laser beam diameter, laser beam fluence, and scan speed using CdS quantum dots (QDs) as a template and dopamine as a functional monomer. A non-covalent imprinting approach was employed in this study due to the simplicity of preparation. Simple oxidative polymerization of the dopamine that creates the self-assembly monolayer seems to be an ideal choice. The QDs prepared by UV light irradiation synthesis were stabilized by using mercaptosuccinic acid. Formation of a complex of QD-antibody and QD-antibody-antigen was verified by using capillary electrophoresis with laser-induced fluorescence detection. QDs and antibody were connected together via an affinity peptide linker. LA-ICP-MS was employed as a proof-of-concept for detection method of two types of immunoassay: 1) antigen extracted from the sample by MIP and subsequently overlaid/immunoreacted by QD-labelled antibodies, 2) complex of antigen, antibody, and QD formed in the sample and subsequently extracted by MIP. The first approach provided higher sensitivity (MIP/NIP), however, the second demonstrated higher selectivity. A mixture of proteins with size in range 10–250 kDa was used as a model sample to demonstrate the capability of both approaches for detection of IgG in a complex sample.

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A label-free detection of diethylstilbestrol based on molecularly imprinted polymer-coated upconversion nanoparticles obtained by surface grafting

Cited by 15 publications

References 32 publications

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Preparation of magnetic molecularly imprinted polymers for the rapid detection of diethylstilbestrol in milk samples

CdS quantum dots-based immunoassay combined with particle imprinted polymer technology and laser ablation ICP-MS as a versatile tool for protein detection

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