A label-free immunosensor for diagnosis of dengue infection with simple electrical measurements

Fang, Xiaoqin; Tan, Ooi Kiang; Tse, Man Siu; Ooi, Eng Eong

doi:10.1109/icsens.2009.5398396

Cited by 9 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is defined as a group of metabolic diseases where ultimately the body's pancreas does not produce enough insulin or does not properly respond to insulin produced, resulting in high blood sugar levels over a prolonged period. Glucose meters and other POC devices utilize an assortment of methods for detecting and monitoring biomarkers including electrochemical [16][17][18][19][20], magnetic [21][22][23][24][25][26][27][28][29][30], optical [31][32][33][34], label-free spectroscopic analysis [35][36][37][38][39][40][41][42][43], colorimetric [44][45][46][47][48][49], and plasmonic nanoparticle based sensors [50][51][52]. Generally, electrochemical detection uses potentiometric, amperometric, and impedimetric measurements in conjunction with electroactive tags or free flowing electroactive analytes [17][18][19][20] [15,53,54] are examples of electrochemical and colorimet...…”

Section: Current Commercial Poc Technologiesmentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

et al. 2017

View full text Add to dashboard Cite

Point-of-care (POC) device development is a growing field that aims to develop low-cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, selfcontained, and can be used anywhere -from modern clinics to remote and low resource areas. In this review, surface enhanced Raman spectroscopy (SERS) is discussed as a solution to facilitating the translation of bioanalytical sensing to the POC. The potential for SERS to meet the widely accepted "ASSURED" (Affordable, Sensitive, Specific, Userfriendly, Rapid, Equipment-free, and Deliverable) criterion provided by the World Health Organization is discussed based on recent advances in SERS in vitro assay development. As SERS provides attractive characteristics for multiplexed sensing at low concentration limits with a high degree of specificity, it holds great promise for enhancing current efforts in rapid diagnostic testing. In outlining the progression of SERS techniques over the past years combined with recent developments in smart nanomaterials, high-throughput microfluidics, and low-cost paper diagnostics, an extensive number of new possibilities show potential for translating SERS biosensors to the POC.

show abstract

Section: Current Commercial Poc Technologiesmentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

et al. 2017

View full text Add to dashboard Cite

show abstract

“…132,137,138 The conventional EIS is mainly based on the Faradaic process where charge is transferred across the interface. 134 ) reduces the activity of the protein layer. An immunosensor based on non-Faradaic process, a nonlabeling methodology, has also been researched and has proved to be somewhat more accessible to point-of-care applications.…”

Section: Electrochemical Impedance Biosensorsmentioning

confidence: 99%

“…[130][131][132][133][134][135][136] Also EIS can be involved in biosensing of viral pathogens as hybridization immunobiosensors. 132,137,138 The conventional EIS is mainly based on the Faradaic process where charge is transferred across the interface.…”

Section: Electrochemical Impedance Biosensorsmentioning

confidence: 99%

Nanoscale virus biosensors: state of the art

Krejčová¹,

Michálek²,

Rodrigo³

et al. 2015

NDD

View full text Add to dashboard Cite

Abstract:Since the beginning of the new millennium, viruses have shown huge epidemiological and pandemic potential: severe acute respiratory syndrome (SARS) in 2002, pandemic swine flu in 2009, and last but not least the West African Ebola outbreak in 2014. The occurrence and spread of the new virus in pandemic dimension poses a threat to the health and lives of 7 billion people worldwide. There is a growing urgency for highly sensitive and selective detection techniques, usable for a wide number of applications, including disease diagnosis, pharmaceutical research, agriculture, as well as preventive measures. Nanobiosensors represent a new promising tool for virus detection. This review gives a brief survey of the issue of viral detection, comprising diagnostics of target structure of viruses such as nucleic acids or proteins. This review covers different detection principles, methods of fabrication, and applications of virus biosensors.

show abstract

“…With impedance spectroscopy and I-V measurements, it was possible to detect Dengue antibodies in human serum even after a 50 000-fold dilution. Since Dengue infection is also diagnosed using the salivary antibodies, of which the concentration is relatively close to the concentration in serum, the sensor could possibly be employed in an easy, rapid point-of-care setting (Fang et al, 2010). Pan et al (2010) developed an amperometric immunosensor for the diagnosis of Urinary Tract Infection (UTI), using lactoferrin (LTF) as a biomarker for UTI.…”

Section: Clinical Diagnosticsmentioning

confidence: 99%

“…For this reason, focus has shifted towards electronic, label-free immunosensors. Fang et al (2010) described the development of a novel immunosensor based on a sol-gel derived Barium Strontium Titanate (BST) thin film and interdigitated electrodes for the diagnosis of Dengue infection. The Dengue virus particles were immobilized onto the electrodes, to capture the Dengue antibodies present in human serum.…”

Section: Clinical Diagnosticsmentioning

confidence: 99%