A label-free photoelectrochemical biosensor for urokinase-type plasminogen activator detection based on a g-C3N4/CdS nanocomposite

Liu, Xing-Pei; Chen, Jingshuai; Mao, Chang‐Jie; Niu, Helin; Song, Ji‐Ming; Jin, Baokang

doi:10.1016/j.aca.2018.04.051

Cited by 30 publications

(7 citation statements)

References 42 publications

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“…CdS QDs were synthesized according to the previous literature with some modifications. 23 First, 172 μL of 3-mercaptopropionic acid (3-MPA) and 40 mL of CdCl 2 aqueous solution (20 mM) were mixed in a three-necked flask. Then, the pH value was adjusted to 11 using NaOH (1.0 M) aqueous solution.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF₁₆₅ Subtype

et al. 2022

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The recent surge of interest in metal–organic gels (MOGs) has emerged for their soft porous structure, large surface area, and abundant active metal sites, making them a promising candidate for building catalyst matrices. In this work, facilely synthesized Fe(III)-organic gel was directly used as a robust electrode matrix. Detailed studies illustrated that their Fe(III) centers can speed up the electro-oxidation/reduction of the H2O2 coreactant to produce reactive oxygen species for enhancing a potential-resolved dual electrochemiluminescence (ECL) emission. Among them, the anodic signal of luminol varied with the cell concentration based on the impedance ECL mechanism, while the cathodic signal of CdS quantum dots traced the VEGF165 subtype at cell surface by specific aptamer recognition. Based on this, a ratiometric strategy was proposed for accurate cytosensing by eliminating environmental interference. Moreover, by cooperating these two signals, a novel strategy was developed for direct evaluation of the VEGF165 subtype, further realizing rapid drug screening and subtype assessment on different cell lines. This work not only opens up the promising application of MOGs as an effective catalyst matrix but also develops reliable cell assays and protein subtype identification for clinical diagnosis and research.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF₁₆₅ Subtype

et al. 2022

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“…105,106 In view of the high light stability and absorption coefficient of Ti 3 C 2 , it is considered to be one of the most promising lightabsorbing materials. 107 Liu et al combined Ti 3 C 2 with CD sulfide (CdS), which has outstanding photoelectric properties in the visible light range, to form a novel photoelectric nanocomposite (Figure 6B). The band gap of Ti 3 C 2 can match the energy level of CdS.…”

Section: ■ Design Strategy Of Electrochemical Biosensor For Breast Ca...mentioning

confidence: 99%

Electrochemical Biosensors for the Analysis of Breast Cancer Biomarkers: From Design to Application

Jing

Xie

et al. 2021

Anal. Chem.

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“…Currently, a combination of two detection mechanisms, photoelectrochemical (PEC) biosensing, is used, which can verify the concentration of the analyte using both electrical and optical methods simultaneously. [54][55][56][57][58][59][60] 4.1.1 g-CN-based biosensors with electrochemiluminescence (ECL) properties. Electrochemiluminescence (ECL) or electrochemical chemiluminescence is the luminescence that occurs during an electrochemical reaction in solution.…”

Section: G-cn Qds For Other Biological Applicationsmentioning

confidence: 99%

Graphitic carbon nitride-based nanocomposites and their biological applications: a review

2019

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A label-free photoelectrochemical biosensor for urokinase-type plasminogen activator detection based on a g-C3N4/CdS nanocomposite

Cited by 30 publications

References 42 publications

An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF₁₆₅ Subtype

An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF₁₆₅ Subtype

Electrochemical Biosensors for the Analysis of Breast Cancer Biomarkers: From Design to Application

Graphitic carbon nitride-based nanocomposites and their biological applications: a review

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A label-free photoelectrochemical biosensor for urokinase-type plasminogen activator detection based on a g-C3N4/CdS nanocomposite

Cited by 30 publications

References 42 publications

An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF165 Subtype

An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF165 Subtype

Electrochemical Biosensors for the Analysis of Breast Cancer Biomarkers: From Design to Application

Graphitic carbon nitride-based nanocomposites and their biological applications: a review

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Product

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An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF₁₆₅ Subtype

An Iron(III)-Based Metal–Organic Gel-Catalyzed Dual Electrochemiluminescence System for Cytosensing and In Situ Evaluation of the VEGF₁₆₅ Subtype