2023
DOI: 10.3390/diagnostics13182940
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A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma

Christopher S. Boot

Abstract: Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accurate and timely diagnosis is essential. The initial diagnosis of phaeochromocytoma/paraganglioma (PPGL) is often dependent on biochemical testing. There is a range of pre-analytical, analytical and post-analytical f… Show more

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Cited by 4 publications
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“…Furthermore, unlike general tumors, endocrine-related tumors generally have a relatively favorable prognosis. For PPGL, the 5-year survival rate after surgery for non-metastatic tumors can reach 95%, whereas, for tumors that have metastasized, the 5-year survival rate is approximately 30-40% [128] ; thus, factors contributing to cachexia require confirmation.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, unlike general tumors, endocrine-related tumors generally have a relatively favorable prognosis. For PPGL, the 5-year survival rate after surgery for non-metastatic tumors can reach 95%, whereas, for tumors that have metastasized, the 5-year survival rate is approximately 30-40% [128] ; thus, factors contributing to cachexia require confirmation.…”
Section: Discussionmentioning
confidence: 99%